Biomarkers · Chemical
We have not added a physiological summary for this biomarker yet. Compare the commercial laboratory assays and population reference ranges below.
Check orderable catalog codes, specimen types, fasting requirements, and demographic reference ranges across laboratories.
Laboratory assay overview
This test is used to identify the presence and follow the course of disseminated intravascular coagulation (DIC), including abnormalities in platelet count, fibrinogen, fibrin split products, and fibrinolytic activity.
Labcorp test directory, test code 117853
Labcorp test directory, test code 500041
Laboratory assay overview
This test is used to evaluate an isolated prolonged PT or for evaluation when both the aPTT and PT are prolonged and to assess factor V activity level.6-8
Labcorp population reference ranges
Labcorp calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| Age | Range |
| 1 d | 64–103% |
| 3 d | 92–154% |
| 1 to 11 m | 94–141% |
| 1 to 5 y | 67–127% |
| 6 to 10 y | 56–141% |
| 11 to 16 y | 67–141% |
| >16 y | 64–166% |
‘Factor V Activity14-16 Age | Range 1 d | 64–103% 3 d | 92–154% 1 to 11 m | 94–141% 1 to 5 y | 67–127% 6 to 10 y | 56–141% 11 to 16 y | 67–141% >16 y | 64–166%
Labcorp test directory, test code 086249
Laboratory assay overview
This panel quantifies coagulation factor V activity and inhibitors to factor V and may be used to support the diagnosis of factor V deficiency as a result of inhibitor development. Coagulation factor V plays an essential role in hemostasis by promoting thrombin generation at the activated platelet surface. Deficiency of factor V leads to a rare bleeding disorder and can be congenital or acquired. Congenital factor V deficiency is caused by pathogenic variants of the F5 gene, while acquired factor V deficiency can be caused by liver disease, consumptive coagulopathies, disseminated intravascular coagulation, or inhibitors (autoantibodies or alloantibodies) that interfere with factor V activity. Inhibition of factor V activity secondary to antibody development is a rare occurrence and may be induced by chemical agents, drugs, or surgical procedures using bovine thrombin [1]. Patients with inhibitors to factor V usually have prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), low factor V activity levels, and a normal thrombin time. Factor V inhibitors are measured using a Bethesda assay and are reported in Bethesda titer units (BU). Quantification of factor V inhibitors may inform treatment decisions for acquired factor V deficiency and help monitor inhibitor suppression therapy [1]. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings. Reference 1. Tabibian S, et al. Semin Thromb Hemost. 2019;45(5):523-543.
Quest Diagnostics population reference ranges
Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| Factor V Activity | 65-150 | % normal |
| Factor V Human Inhibitor | ≤0.4 | BU |
Factor V Activity 65-150 % normal Factor V Human Inhibitor ≤0.4 BU
Quest Diagnostics test directory, test code 17844
Laboratory assay overview
This profile measures factor V activity and reflexes to the measurement of factor V inhibitor level (Bethesda titer) when the activity level is diminished to 40 percent or less.
Labcorp population reference ranges
Labcorp calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| Age | Range |
| 1 d | 64–103% |
| 3 d | 92–154% |
| 1 to 11 m | 94–141% |
| 1 to 5 y | 67–127% |
| 6 to 10 y | 56–141% |
| 11 to 16 y | 67–141% |
| >16 y | 64–166% |
Age | Range 1 d | 64–103% 3 d | 92–154% 1 to 11 m | 94–141% 1 to 5 y | 67–127% 6 to 10 y | 56–141% 11 to 16 y | 67–141% >16 y | 64–166%
Labcorp test directory, test code 086250
Laboratory assay overview
This test measures coagulation factor V activity and may be used to help determine the cause of a prolonged prothrombin time (PT) or activated partial thromboplastin time (aPTT). Coagulation factor V plays an essential role in hemostasis by promoting thrombin generation at the activated platelet surface. Deficiency of factor V leads to a rare bleeding disorder and can be congenital or acquired. Congenital factor V deficiency, also known as parahemophilia or Owren's disease, has an incidence of 1 per one million [1] and is caused by pathogenic variants of the F5 gene, which encodes factor V. Acquired factor V deficiency can be caused by liver disease, consumptive coagulopathies, disseminated intravascular coagulation, or inhibitors (autoantibodies or alloantibodies) that interfere with factor V activity. Inhibitors to factor V may be induced by chemical agents, drugs, or surgical procedures using bovine thrombin [1]. Factor activity assays, including factor V activity assay, are usually indicated in patients with bleeding symptoms and prolonged PT and aPTT [1]. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings. Reference 1. Tabibian S, et al. Semin Thromb Hemost. 2019;45(5):523-543.
65-150 % normal
Quest Diagnostics test directory, test code 344
Laboratory assay overview
Determine the cause of an extended prothrombin time
Labcorp test directory, test code 117866
We compile every detail above directly from named laboratory directories and published clinical studies. Laboratories calculate standard reference intervals from the statistical distribution of tested populations for a specific assay method and demographic group, rather than setting universal optimal targets.
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