CD16A (FCGR3A) F158V Polymorphism Analysis
- Laboratory
- Quest Diagnostics
- Test code
- 34493
- Specimen
- Blood
- Fasting
- Not stated
- LOINC
- 100717-8, 101545-2, 101546-0
- Turnaround
- Set up: Wed, Sat
Laboratory assay overview
CD16A (FCGR3A) F158V Polymorphism Analysis - The CD16A (FCGR3A) gene encodes for an Fc-gamma receptor on human white blood cells which plays an important role in antibody dependent cell-mediated cytotoxicity (ADCC). In cancer patients, differential clinical response to therapeutic monoclonal antibodies has been reported to correlate with the genotype of the CD16A (FCGR3A) gene (PMID: 23286345, PMID: 30374078, PMID 33480963). The different genotypes (V/V, F/V, or F/F) result from a single nucleotide polymorphism, dbSNP rs396991, where a T>G substitution changes phenylalanine (F) to valine (V) at position 158 (P08637 VAR 003960).
Quest Diagnostics population reference ranges
Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| CD16A (FCGR3A) F158V | Not detected |
| F158 | Not detected |
| V158 | Not detected |
View complete laboratory reference notes
CD16A (FCGR3A) F158V Not detected F158 Not detected V158 Not detected
Quest Diagnostics test directory, test code 34493