Autoimmune Nodopathy (CIDP-like) Evaluation
- Laboratory
- Quest Diagnostics
- Test code
- 18702
- Specimen
- Serum
- Fasting
- Not stated
- LOINC
- 106739-6, 106741-2, 106785-9, 8251-1
- Turnaround
- Set up: Sun, Thurs
Laboratory assay overview
Chronic autoimmune peripheral neuropathies include a variety of disorders. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) defines a syndrome with chronic symmetrical proximal and distal muscle weakness and areflexia. Several subtypes have been recognized, depending on whether there is localization and/or predominance of motor or sensory symptoms. Previously considered a type of CIDP, patients in whom autoantibodies to components of the myelinated nerve node or paranode are present have been characterized as having a separate syndrome. It differs from CIDP in presentation (patients often have ataxia and tremor), pathogenesis (absence of significant inflammatory infiltrate suggest that antibodies have a direct effect), and response to treatment (unlike patients with CIDP, it is unlikely to respond to IVIg and may need alternative therapy, such as rituximab). The separate syndrome has been termed autoimmune nodopathy. Testing for the associated autoantibodies can help distinguish it for CIDP.
Quest Diagnostics population reference ranges
Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| Neurofascin 155 Ab | Negative |
| Neurofascin 186 Ab | Negative |
| Contactin 1 Ab | Negative |
| CNTN1/CASPR1 Ab | Negative |
View complete laboratory reference notes
Neurofascin 155 Ab | Negative Neurofascin 186 Ab | Negative Contactin 1 Ab | Negative CNTN1/CASPR1 Ab | Negative
Quest Diagnostics test directory, test code 18702