- Laboratory
- Quest Diagnostics
- Test code
- 7018
- Specimen
- Serum
- Fasting
- Not stated
- LOINC
- 1869-7, 1874-7, 1884-6
Laboratory assay overview
Apolipoprotein A1 is the primary protein associated with HDL cholesterol. Like HDL cholesterol, increased concentrations are associated with reduced risk of cardiovascular disease. Apolipoprotein B-100 is the primary protein associated with LDL cholesterol and other lipid particles. Like LDL cholesterol, increased concentrations are associated with increased risk of cardiovascular disease. The ratio of these two apolipoproteins correlates with risk of cardiovascular disease.
Quest Diagnostics population reference ranges
Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|
| Male | ≥115 mg/dL | |
| Female | ≥125 mg/dL | |
| Risk Category | Male | Female |
| Optimal | ≥115 mg/dL | ≥125 mg/dL |
| High | <115 mg/dL | <125 mg/dL |
| Apolipoprotein B | <90 mg/dL |
| Risk Category | not stated |
| Optimal | <90 mg/dL |
| Moderate | 90-129 mg/dL |
| High | ≥130 mg/dL |
| Male | <0.77 | |
| Female | <0.63 | |
| Risk Category | Male | Female |
| Optimal | <0.77 | <0.63 |
| Moderate | 0.77-0.95 | 0.63-0.78 |
| High | >0.95 | >0.78 |
View complete laboratory reference notes
Apolipoprotein A1
Male | ≥115 mg/dL
Female | ≥125 mg/dL
Risk Category | Male | Female
Optimal | ≥115 mg/dL | ≥125 mg/dL
High | <115 mg/dL | <125 mg/dL
Cardiovascular event risk category cut points (optimal, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.
Apolipoprotein B | <90 mg/dL
Risk Category
Optimal | <90 mg/dL
Moderate | 90-129 mg/dL
High | ≥130 mg/dL
A desirable treatment target may be <80 mg/dL or lower depending on the risk category of the patient including patients on lipid lowering therapies, patients with ASCVD, diabetes with >1 risk factors, Stage 3 or greater CKD with albuminuria, or heterozygous familial hypercholesterolemia. ApoB relative risk category cut points are based on AACE/ACE and ACC/AHA recommendations (Grundy SM, et al. 2019. doi:10.1016/j.jacc.2018.11.002; Handelsman Y, et al. 2020. doi:10.4158/CS-2020-0490).
Apolipoprotein B/A1 Ratio
Male | <0.77
Female | <0.63
Risk Category | Male | Female
Optimal | <0.77 | <0.63
Moderate | 0.77-0.95 | 0.63-0.78
High | >0.95 | >0.78
Cardiovascular event risk category cut points (optimal, moderate, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.