Immunoglobulin A (IgA) Heavy and Light Chain (HLC) Pairs, κ and λ With Ratio
- Laboratory
- Labcorp
- Test code
- 123540
- Specimen
- Serum
- Fasting
- Not stated
- Turnaround
- 4 - 6 days
Laboratory assay overview
For the quantitative measurement of human IgA heavy chain and light chain intact immunoglobulin in serum. The result can be used when monitoring previously diagnosed IgA multiple myeloma patients and is used in conjunction with other clinical and laboratory findings. Heavy and light chain pair quantitation may be useful for: 1. Distinguishing between broadly migrating monoclonal proteins and restricted polyclonal immunoglobulin patterns on serum protein electrophoresis. 2. Quantitating monoclonal IgA proteins that are difficult to quantitate using serum protein electrophoresis alone. 3. Providing a more specific quantitation of the monoclonal protein than total IgA measurements alone.
View complete laboratory reference notes
• IgA κ (g/L): 0.48−2.82 • IgA λ (g/L): 0.36−1.98 • IgA κ:IgA λ ratio: 0.80−2.04 An elevated IgA heavy and light chain (HLC) pair ratio suggests a clonal proliferation of an IgA κ clone of plasma cells. A low IgA HLC pair ratio suggests a clonal proliferation of an IgA λ clone of plasma cells.
Labcorp test directory, test code 123540