Biomarkers · Chemical
We have not added a physiological summary for this biomarker yet. Compare the commercial laboratory assays and population reference ranges below.
Check orderable catalog codes, specimen types, fasting requirements, and demographic reference ranges across laboratories.
Laboratory assay overview
Therapeutic drug management
Carbamazepine: 4.0−12.0 µg/mL; carbamazepine-10,11-epoxide: 0.4−4.0 µg/mL
Labcorp test directory, test code 803189
Quest Diagnostics population reference ranges
Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| Carbamazepine, Free | 1.0-3.0 mcg/mL |
| Carbamazepine Metabolite, Free | 0.1-1.0 mcg/mL |
Carbamazepine, Free 1.0-3.0 mcg/mL Carbamazepine Metabolite, Free 0.1-1.0 mcg/mL
Quest Diagnostics test directory, test code 6071
Laboratory assay overview
Carbamazepine and its metabolite (10,11-carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders. The metabolism of carbamazepine in epileptic patients has several different pathways that can be altered when the patient is co-medicated with other anticonvulsants and, therefore, it's therapeutic level should be monitored along with its metabolite in their free and protein bound states.
See Laboratory Report
Quest Diagnostics test directory, test code 7933
Laboratory assay overview
Carbamazepine and its metabolite (10,11-carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders. The metabolism of carbamazepine in epileptic patients has several different pathways that can be altered when the patient is co-medicated with other anticonvulsants and, therefore, it's therapeutic level should be monitored along with its metabolite in their free and protein bound states.
Carbamazepine, Total | 4.0-12.0 mcg/mL Carbamazepine Metabolite, Total | 0.2-2.0 mcg/mL
Quest Diagnostics test directory, test code 26513
Laboratory assay overview
This heterocyclic (iminostilbene) compound has potent antiepileptic properties and is effective alone or with other antiepileptic drugs in partial seizures, especially complex partial seizures, generalized tonic-clonic seizures, and combinations of these seizure types. Carbamazepine generally is ineffective for absence, myoclonic, and atonic seizures. In children with symptomatic generalized epilepsy and continuous spike-and-wave discharge, these seizure types may develop or tonic-clonic seizures may increase in frequency with use of carbamazepine. It has also been noted1 that the dose of carbamazepine cannot be used as a reliable index for predicting the serum concentration of either total or free carbamazepine serum concentrations in children with epilepsy. Comparative clinical trial data indicate that patients with partial seizures may tolerate carbamazepine better than phenobarbital and primidone, but individual responses vary. Many clinicians consider carbamazepine a drug of choice for initial therapy in idiopathic and symptomatic localization-related epilepsies, especially in children and women. This drug is increasingly preferred to phenobarbital in pediatric patients because it has less effect on cognition and behavior. It is reported to have psychotropic activity that may increase alertness and elevate mood in depressed epileptic patients, but not in otherwise normal patients. Mental improvements may be due to substitution of carbamazepine for sedative drugs, control of seizures, or a direct psychotropic effect. Carbamazepine can induce the hepatic enzymes CYP3A4, CYP1A2, and CYP2C9, resulting in decreased serum levels of many drugs (eg, alprazolam, clozapine, diazepam, haloperidol, risperidone, and tricyclic antidepressants).2
Therapeutic: In conjunction with other antiepileptic drugs: 4.0−8.0 μg/mL; carbamazepine alone: 6.0−12.0 μg/mL
Labcorp test directory, test code 007419
4.0-12.0 mcg/mL
Quest Diagnostics test directory, test code 18949
Laboratory assay overview
Carbamazepine is an anticonvulsant which is structurally related to the tricyclic antidepressants and is useful in treating patients with temporal lobe epilepsy. Carbamazepine levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.
4.0-12.0 mg/L
Quest Diagnostics test directory, test code 329
We compile every detail above directly from named laboratory directories and published clinical studies. Laboratories calculate standard reference intervals from the statistical distribution of tested populations for a specific assay method and demographic group, rather than setting universal optimal targets.
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