Citric Acid, U, 24hr, Urine

Understand what Citric Acid, U, 24hr, Urine signals

Primary unit: mg/24 hr
LOINC codes: 3167-4, 6687-8, 2162-6, 24447-5, 25308-8, 26889-6, 2701-1, 27378-9, 2779-7, 2829-0, 2956-1, 3087-4, 34736-9, 35090-0, 42673-4, 42678-3, 43423-3, 53811-6, 6874-2, 8251-1
Commercial laboratory assays: 6

We have not added a physiological summary for this biomarker yet. Compare the commercial laboratory assays and population reference ranges below.

Compare commercial laboratory assays for Citric Acid, U, 24hr, Urine

Check orderable catalog codes, specimen types, fasting requirements, and demographic reference ranges across laboratories.

Citric Acid (Citrate), 24-Hour Urine

Laboratory: Labcorp
Test code: 016865
Specimen: Urine
Fasting: Not stated
Turnaround: 2 - 7 days

Laboratory assay overview

The mean urinary citrate excretion rate in patients with idiopathic calcium urolithiasis has been found to be significantly lower than that of control groups. Hypocitraturia is common in patients with urolithiasis resulting from renal tubular acidosis and in patients with enteric hyperoxaluria. Citrate excretion is low in renal insufficiency.

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320−1240 mg/24 hours

Labcorp test directory, test code 016865

Citric Acid, 24-Hour Urine without Creatinine

Laboratory: Quest Diagnostics
Test code: 11315
Specimen: Urine
Fasting: Not stated
LOINC: 3167-4, 6687-8
Turnaround: Set up: Tues-Sat

Laboratory assay overview

This quantitative citric acid test, performed with a 24-hour urine specimen, may help assess the risk of calcium stone formation in the kidneys and inform patient management [1]. In general, 24-hour urine specimens are preferred to random urine specimens when measuring citric acid for diagnostic evaluation and monitoring of calcium nephrolithiasis [2]. Citrate inhibits calcium stone formation by binding and solubilizing calcium, which reduces supersaturation of calcium salts [1-2]. Approximately half of the patients with calcium stones have decreased urinary citrate levels [1]. Citrate is among several substances routinely screened to evaluate the risk of forming kidney stones. Low urinary citrate levels may indicate oral citrate treatment in patients with recurrent calcium nephrolithiasis [1]. Other conditions that can cause hypocitraturia include distal renal tubular acidosis, malabsorption, and urinary tract infection [1]. This test is also available with creatinine (Citric Acid, 24-Hour Urine with Creatinine). Because daily urine excretion of creatinine fluctuates little, creatinine excretion can help determine if 24-hour urine specimens for citric acid have been completely and accurately collected [1]. The urinary citric acid level cannot be used to estimate dietary intake because other factors, such as acid-base balance, may affect citrate excretion [2]. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings. ⁠⁠⁠⁠⁠⁠⁠References 1. Delaney, PM et al. Kidney disease. In: Rifai R, et al. eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier Inc; 2022. 2. Williams JC Jr, et al. Urolithiasis. 2021;49(1):1-16.

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100-1300 mg/24 h

Quest Diagnostics test directory, test code 11315

Litholink 24-Hour Urine Cystine Profile

Laboratory: Labcorp
Test code: 910245
Specimen: Urine
Fasting: Not stated
Turnaround: 4 - 8 days

Laboratory assay overview

This test is used for people with known cystinuria, cystine stone formers or patients who had a reported "positive" screen from the standard Litholink test, Litholink 24-Hour Urine, KS [910235].

Labcorp test directory, test code 910245

Litholink 24-Hour Urine, KS

Laboratory: Labcorp
Test code: 910235
Specimen: Urine
Fasting: Not stated
Turnaround: 4 - 8 days

Laboratory assay overview

This test is used for treatment and management of known or suspected kidney stone formers.

Labcorp test directory, test code 910235

StoneRisk® Panel

Laboratory: Quest Diagnostics
Test code: 442
Specimen: Urine
Fasting: Not stated
LOINC: 2162-6, 24447-5, 25308-8, 26889-6, 2701-1, 27378-9, 2779-7, 2829-0, 2956-1, 3087-4, 3167-4, 34736-9, 35090-0, 42673-4, 42678-3, 43423-3, 53811-6, 6687-8, 6874-2, 8251-1
Turnaround: Set up: Mon-Sat

Laboratory assay overview

StoneRisk® Panel is for stone formers with a positive urine culture indicating urinary tract infection (UTI), also for recurrent stone formers or when attending physician deems it medically necessary for the patient to have comprehensive metabolic evaluation.

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See Laboratory Report

Quest Diagnostics test directory, test code 442

UroRisk® Panel

Laboratory: Quest Diagnostics
Test code: 15565
Specimen: Urine
Fasting: Not stated
LOINC: 2162-6, 24447-5, 26889-6, 2701-1, 27378-9, 2779-7, 2829-0, 2956-1, 3087-4, 3167-4, 34736-9, 35090-0, 42673-4, 42678-3, 43423-3, 6687-8, 6874-2, 8251-1
Turnaround: Set up: Mon-Sat

Laboratory assay overview

UroRisk® Panel is recommended for initial and recurrent stone formers (excluding patients with Struvite stones).

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See Laboratory Report

Quest Diagnostics test directory, test code 15565

Verify these ranges and sources

We compile every detail above directly from named laboratory directories and published clinical studies. Laboratories calculate standard reference intervals from the statistical distribution of tested populations for a specific assay method and demographic group, rather than setting universal optimal targets.

Always review your personal lab results with a licensed clinician, or track your lab history and health goals in Aumnivida.

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