Myeloproliferative Neoplasms (MPN) Mini Panel
- Laboratory
- Quest Diagnostics
- Test code
- 13221
- Specimen
- Blood
- Fasting
- Not stated
- LOINC
- 107254-5, 107255-2, 30896-5, 48726-4, 51968-6
- Turnaround
- Set up: Sun, Tues, Thurs
Laboratory assay overview
The MPN mini profile detects disease-defining, potentially targetable mutations in JAK2, CALR, and MPL for myeloproliferative neoplasms. These 3 genes are growth- promoting oncogenes that operate through a signaling pathway mediated by JAK2, and MPNs with these mutations can respond to clinically available JAK2 inhibitors. The inclusion of hot spot mutation testing in these 3 genes into the routine workup of MPNs is recommended by the World Health Organization's classifications of hematological malignancies and the National Comprehensive Cancer Network (NCCN) guidelines. This combined testing method provides diagnostic assistance, provides a clonal molecular marker of disease following diagnosis and post therapy follow-up, influences prognosis, and identifies those MPNs that may potentially benefit from JAK2 inhibitor therapy.
Quest Diagnostics population reference ranges
Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| JAK2 Variant | Not detected |
| MPL Variant | Not detected |
| CALR Variant | Not detected |
View complete laboratory reference notes
JAK2 Variant | Not detected MPL Variant | Not detected CALR Variant | Not detected
Quest Diagnostics test directory, test code 13221