IGF Binding Protein-2 (IGFBP-2)
- Laboratory
- Quest Diagnostics
- Test code
- 37102
- Specimen
- Serum
- Fasting
- Not stated
- LOINC
- 12723-3
- Turnaround
- Set up: Tues (p.m.)
Laboratory assay overview
This test measures serum concentration of insulin-like growth factor binding protein 2 (IGFBP-2). The value of testing IGFBP-2 has been researched for various disorders, including obesity, type 2 diabetes, cancer, and Alzheimer disease [1,2]. IGFBP-2 belongs to the IGFBP family of 6 proteins that bind and transport insulin-like growth factors (IGFs) and regulate IGF bioavailability. IGFBP-2 is present in very high concentrations during fetal development, progressively falling after birth. Among the 6 IGFBPs, IGFBP-2 has been involved in the IGF activity in most organs, and its role, either dependent or independent of IGFs, has been implicated in bone growth, metabolism, and malignancy [1]. The clinical application of IGFPB-2 measurement was explored in numerous studies but has not been well-established. IGFBP-2 is the most abundantly expressed IGFBPs in several cancers, such as glioma, prostate, breast, and ovarian cancers, possibly contributing to the aggressiveness of these cancers [1]. Low levels of IGFBP-2 are associated with obesity, type 2 diabetes mellitus, and metabolic syndrome [1]. The therapeutic potential of IGFPB-2 has been investigated preclinically in increasing insulin sensitivity, decreasing adipogenesis, and inhibiting tumor growth and metastasis. Additionally, IGFBP-2 levels were correlated with cognitive outcomes, possibly by inhibiting the neuroprotective effects of IGFs in the brain. Cognitively healthy adults with elevated levels of IGFBP-2 may have higher risk to develop all-cause dementia and Alzheimer disease dementia [2]. Therefore, IGFBP-2 has been suggested as a potential risk predictor and therapeutic candidate for dementia [2]. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings. References 1. Yau SW, et al. J Cell Commun Signal. 2015;9(2):125-142. 2. McGrath ER, et al. Ann Clin Transl Neurol. 2019;6(9):1659-1670.
Quest Diagnostics population reference ranges
Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.
| Population | Range |
|---|---|
| 18-49 Years | 38-267 ng/mL |
| >49 Years | 47-350 ng/mL |
| 5-9 Years | 49-208 ng/mL |
| 10-13 Years | 41-167 ng/mL |
| 14-17 Years | 37-135 ng/mL |
View complete laboratory reference notes
Adult 18-49 Years 38-267 ng/mL >49 Years 47-350 ng/mL Pediatric 5-9 Years 49-208 ng/mL 10-13 Years 41-167 ng/mL 14-17 Years 37-135 ng/mL
Quest Diagnostics test directory, test code 37102