18-Hydroxycorticosterone, S

Understand what 18-Hydroxycorticosterone, S signals

Primary unit: ng/dL
LOINC codes: 1674-1, 1657-6, 1668-3, 1763-2
Commercial laboratory assays: 4

We have not added a physiological summary for this biomarker yet. Compare the commercial laboratory assays and population reference ranges below.

Compare commercial laboratory assays for 18-Hydroxycorticosterone, S

Check orderable catalog codes, specimen types, fasting requirements, and demographic reference ranges across laboratories.

18-Hydroxycorticosterone

Laboratory: Quest Diagnostics
Test code: 94621
Specimen: Serum
Fasting: Not stated
LOINC: 1674-1
Turnaround: Set up: Mon, Wed; Report available: 4-9 days

Laboratory assay overview

Primary aldosteronism should be suspected whenever a patient has the triad of hypertension, hypokalemia, and inappropriate renal potassium wasting. The biggest challenge is the differential diagnosis between the more common adrenal adenoma and bilateral hyperplasia. Because adrenal adenomas increase the circulating levels of 18-hydroxycorticosterone (18-OH B), serum levels of 18-OH B may be useful to differentiate them from bilateral adrenal hyperplasia. The cutoff point appears to be about 50 ng/dL of serum. Most values are around 100 ng/dL. The higher the level of this precursor, the greater the possibility that an adrenal adenoma is present. J Clin Endocrinol Metab. 97: 881-9, 2012.

Quest Diagnostics population reference ranges

Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.

Population	Range
Males	≤175 ng/dL
Females	not stated
Pre-Menopausal Mid Follicular	≤98 ng/dL
Pre-Menopausal Surge	≤152 ng/dL
Pre-Menopausal Mid Luteal	36-164 ng/dL
<30 days	Not established
1-11 months	≤165 ng/dL
1 year	≤140 ng/dL
2 years	≤129 ng/dL
3 years	≤128 ng/dL
4 years	≤133 ng/dL
5 years	≤142 ng/dL
6 years	≤151 ng/dL
7 years	≤160 ng/dL
8 years	≤164 ng/dL
9 years	≤166 ng/dL
10 years	≤165 ng/dL
11 years	≤163 ng/dL
12 years	≤159 ng/dL
13 years	≤155 ng/dL
14 years	≤151 ng/dL
15 years	≤146 ng/dL
16 years	≤142 ng/dL
17 years	≤138 ng/dL

View complete laboratory reference notes

Quest Diagnostics test directory, test code 94621

18-Hydroxycorticosterone, Serum (Endocrine Sciences)

Laboratory: Labcorp
Test code: 500778
Specimen: Serum
Fasting: Not stated
Turnaround: 5 - 12 days

View complete laboratory reference notes

• Premature (26 to 28 weeks): day 4: 10−670 ng/dL • Premature (31 to 35 weeks): day 4: 57−410 ng/dL • Full-term Day 3: 31-546 ng/dL • Full-term (31 days to 11 months): 5−220 ng/dL • 12 to 23 months: 18−155 ng/dL • 24 months to 9 years: 6−85 ng/dL • 10 to 14 years: 10−72 ng/dL • Adults: 9−58 ng/dL • 8:00 AM Supine: 4-21 ng/dL • 8 AM supine upright: 5−46 ng/dL

Labcorp test directory, test code 500778

CAH Panel 3 (Aldosterone Synthase Deficiency)

Laboratory: Quest Diagnostics
Test code: 15273
Specimen: Serum
Fasting: Not stated
LOINC: 1657-6, 1668-3, 1674-1, 1763-2

Laboratory assay overview

This panel may be used for differential diagnosis of congenital adrenal hyperplasia (CAH) and aldosterone synthase deficiency. In addition to the analytes included in this panel (17-hydroxyprogesterone, 11-deoxycortisol, 18-hydroxycorticosterone, aldosterone), other tests may be required to establish a diagnosis. CAH is a group of autosomal recessive diseases characterized by deficiencies of enzymes in steroid hormone production. These deficiencies cause imbalances of steroid intermediates and hormones. Clinical manifestations of CAH vary and depend upon the type of defect [1,2]. When symptoms and signs suggest aldosterone deficiency, this panel may be used to assist in diagnosing different types of CAH as well as aldosterone synthase deficiency, an inherited disorder caused by disruption of the final steps of aldosterone biosynthesis [3]. 17-hydroxyprogesterone levels are elevated in patients with 21-hydroxylase deficiency (the cause of 95% of CAH). 11-beta-hydroxylase and P450 oxidoreductase deficiency can also result in elevated 17-hydroxyprogesterone levels, whereas other types of CAH can result in decreased 17-hydroxyprogesterone levels [1,2]. 11-deoxycortisol levels are elevated in patients with 11-beta-hydroxylase deficiency and decreased in patients with P450 cholesterol side-chain cleavage enzyme deficiency [2]. 18-hydroxycorticosterone is markedly elevated in patients with corticosterone methyloxidase (CMO) deficiency type II and mildly decreased in patients with CMO deficiency type I [3]. Aldosterone levels are decreased in patients with most types of CAH and CMO deficiency type II and undetectable in patients with CMO deficiency type I [3]. Other tests and panels are available to help differentiate among different types of CAH and disorders with similar clinical manifestations. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings. References 1. Speiser PW, et al. J Clin Endocrinol Metab. 2018;103(11):4043-4088. 2. El-Maouche D, et al. Lancet. 2017;390(10108):2194-2210 3. White PC. Mol Cell Endocrinol. 2004;217(1-2):81-87.

View complete laboratory reference notes

See Laboratory Report

Quest Diagnostics test directory, test code 15273

Mineralocorticoid Pediatric Profile (Endocrine Sciences)

Laboratory: Labcorp
Test code: 500285
Specimen: Serum
Fasting: Not stated
Turnaround: 6 - 12 days

Labcorp test directory, test code 500285

Verify these ranges and sources

We compile every detail above directly from named laboratory directories and published clinical studies. Laboratories calculate standard reference intervals from the statistical distribution of tested populations for a specific assay method and demographic group, rather than setting universal optimal targets.

Always review your personal lab results with a licensed clinician, or track your lab history and health goals in Aumnivida.

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