IA-2 Autoantibodies

Laboratory assay overview

Diabetes autoantibodies assessment is helpful in identifying and managing patients at risk for development of type 1 diabetes. Published positivity rates for diabetes autoantibodies in new-onset type 1 diabetes patients listed below are based on the combined analysis of GAD-65, ICA 512, insulin antibodies, and ZnT8 antibodies. The combined analysis has a 98% autoimmunity detection rate, with 1.8% diabetic individuals remaining as autoantibody-negative. fewer than 3% of type 2 diabetics have positive antibodies.1 Positive rate in new-onset type 1 diabetes patients: • GAD-65 antibodies = 68% positive • ICA 512 antibodies = 72% positive • Insulin antibodies = 55% positive • ZnT8 antibodies = 63% positive An increase in the number of positive antibodies is associated with a higher likelihood of type 1 diabetes.