Anti-PL-12 Ab

Laboratory assay overview

Anti-histidyl-tRNA synthetase autoantibodies are the most common MSA, comprising 30-40% of Idiopathic Inflammatory Myopathies (IIM), although PL-12 specifically is seen in less than 5% of IIM. Anti-Synthetase antibodies can be found in polymyositis, dermatomyositis or overlap myositis. Symptoms associated with these antibodies include non-erosive arthritis, ILD, fever, mechanic's hands and Raynaud's.

Laboratory assay overview

This Anti-Synthetase Profile is comprised of Anti-Jo-1 Ab, Anti-PL-7 Ab, Anti-PL-12 Ab, Anti-EJ Ab and Anti-OJ Ab. Anti-synthetase syndrome is an autoimmune disease characterized by interstitial lung disease (ILD), non-erosive arthritis, myositis, Raynaud’s phenomenon, unexplained fever and/or mechanic’s hands.1

Laboratory assay overview

Interstitial Lung Disease (ILD) can complicate several collagen vascular diseases, including Systemic Sclerosis (SS),Sjorgens's Syndrome (SjS), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIM), and ANCA-Associated Vasculitis (AAV). Identifying an underlying autoimmune disorder in ILD patients has critical importance in therapuetic decision-making and has a meaningful impact on prognosis.

Laboratory assay overview

A subset of interstitial lung disease (ILD) patients have underlying connective tissue diseases (CTDs). This panel serves as an aid for the diagnosis of CTDs, including rheumatoid arthritis, inflammatory myositis, systemic sclerosis, and Sjogren’s syndrome, that are associated with the development of ILD. If left untreated, these CTD patients may develop lung fibrosis and inflammation. ILD is a direct consequence of these pathological changes. When severe, ILD leads to restrictive lung disease, pulmonary arterial hypertension, and cardiac disease (cor pulmonale).

Laboratory assay overview

Interstitial Lung Disease (ILD) can complicate several collagen vascular diseases including Systemic Sclerosis, Idiopathic Inflammatory Myopathies, Sjogren's Syndrome, Systemic Lupus Erythematosis, Rheumatoid Arthritis, and ANCA-Associated Vasculitis. This profile is designed to identify an underlying autoimmune disorder, assist therapeutic decision-making and assess disease prognosis.

Laboratory assay overview

The MyoMarker 3 Plus Profile can be used to assist in the diagnosis of dermatomyositis, polymyositis and the anti-synthetase syndrome. Furthermore, it allows charcterization of various subsets of these disorders and offers prognostic information.