Biomarkers · Chemical
We have not added a physiological summary for this biomarker yet. Compare the commercial laboratory assays and population reference ranges below.
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Laboratory assay overview
Detect presence of antidepressant drugs
Labcorp test directory, test code 791490
Laboratory assay overview
Imipramine is the most thoroughly studied tricyclic antidepressant for the treatment of agoraphobia and panic disorder. Several small, placebo-controlled studies and open trials have confirmed the panic-blocking effects of this drug; however, many of these studies also employed behavioral therapy, thus obscuring the relative contribution of imipramine. A recent placebo-controlled, dose-response study confirmed that imipramine alone has significant antipanic and antiphobic effects. The best response was obtained at a dosage of 150−200 mg/day (mean, 185 mg/day). Most other studies also emphasize titrating the dosage to establish plasma concentrations within the range used for the treatment of depression; however, some patients may respond to doses <100 mg/day. Imipramine also has been given with high-potency benzodiazepines for panic disorder.
Therapeutic: imipramine + desipramine: 175−300 ng/mL
Labcorp test directory, test code 007468
We compile every detail above directly from named laboratory directories and published clinical studies. Laboratories calculate standard reference intervals from the statistical distribution of tested populations for a specific assay method and demographic group, rather than setting universal optimal targets.
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