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Biomarkers · Chemical

and IgA

Understand what and IgA signals

Commercial laboratory assays
1

We have not added a physiological summary for this biomarker yet. Compare the commercial laboratory assays and population reference ranges below.

Compare commercial laboratory assays for and IgA

Check orderable catalog codes, specimen types, fasting requirements, and demographic reference ranges across laboratories.

IgA Subclasses

Laboratory
Quest Diagnostics
Test code
34188
Specimen
Serum
Fasting
Required

Laboratory assay overview

IgA, the predominant immunoglobulin secreted at mucosal surfaces, consists of 2 subclasses. IgA1 is the major subclass and accounts for 80% of total IgA in serum, whereas IgA2 is the major subclass in secretions such as milk.Low concentrations of IgA2 with normal IgA1 levels suggest an IgA2 deficiency.Antigenic sites on the IgA subclasses are responsible for the anaphylactic transfusion reactions experienced by some patients totally deficient in either IgA1 or IgA2. After repeated transfusions, such patients may produce antibodies to these antigens. Thus, IgA subclasses are useful in evaluating patients with anaphylactic transfusion reactions.Elevated concentrations of IgA2 with normal or low amounts of IgA1 suggest a clonal plasma cell proliferative disorder secreting a monoclonal IgA2. Grossly elevated levels of either subclass can occur in patients with IgA myeloma.IgA subclasses are of further importance in certain pathogenic microorganisms, including Haemophilus influenzae, which are capable of enzymic cleavage of IgA1, leading to partial inactivation of this subclass. Recurrent sinopulmonary infections may, therefore, be related to deficiency of IgA2, which is resistant to these organisms.

Quest Diagnostics population reference ranges

Quest Diagnostics calculates these statistical intervals for this specific assay and demographic group, not as universal optimal targets.

PopulationRange
IgA1not stated
6-11 months1-115 mg/dL
1 year3-120 mg/dL
2 years7-132 mg/dL
3 years11-143 mg/dL
4-7 years23-175 mg/dL
8-11 years33-204 mg/dL
12-17 years47-249 mg/dL
≥18 years46-378 mg/dL
IgA2not stated
6-11 months0-19 mg/dL
1 year0-23 mg/dL
2 years1-23 mg/dL
3 years1-25 mg/dL
4-7 years2-33 mg/dL
8-11 years2-37 mg/dL
12-17 years4-50 mg/dL
≥18 years13-91 mg/dL
IgA, Serumnot stated
Cord Blood1-3 mg/dL
1-28 days2-40 mg/dL
1-3 months3-40 mg/dL
4-6 months7-47 mg/dL
7-11 months12-53 mg/dL
1 year20-73 mg/dL
2 years20-99 mg/dL
3-5 years22-140 mg/dL
6-8 years31-180 mg/dL
9-11 years33-200 mg/dL
12-16 years36-220 mg/dL
17-60 years47-310 mg/dL
≥61 years70-320 mg/dL
View complete laboratory reference notes

IgA1 6-11 months | 1-115 mg/dL 1 year | 3-120 mg/dL 2 years | 7-132 mg/dL 3 years | 11-143 mg/dL 4-7 years | 23-175 mg/dL 8-11 years | 33-204 mg/dL 12-17 years | 47-249 mg/dL ≥18 years | 46-378 mg/dL IgA2 6-11 months | 0-19 mg/dL 1 year | 0-23 mg/dL 2 years | 1-23 mg/dL 3 years | 1-25 mg/dL 4-7 years | 2-33 mg/dL 8-11 years | 2-37 mg/dL 12-17 years | 4-50 mg/dL ≥18 years | 13-91 mg/dL IgA, Serum Cord Blood | 1-3 mg/dL 1-28 days | 2-40 mg/dL 1-3 months | 3-40 mg/dL 4-6 months | 7-47 mg/dL 7-11 months | 12-53 mg/dL 1 year | 20-73 mg/dL 2 years | 20-99 mg/dL 3-5 years | 22-140 mg/dL 6-8 years | 31-180 mg/dL 9-11 years | 33-200 mg/dL 12-16 years | 36-220 mg/dL 17-60 years | 47-310 mg/dL ≥61 years | 70-320 mg/dL

Quest Diagnostics test directory, test code 34188

Verify these ranges and sources

We compile every detail above directly from named laboratory directories and published clinical studies. Laboratories calculate standard reference intervals from the statistical distribution of tested populations for a specific assay method and demographic group, rather than setting universal optimal targets. Always review your personal lab results with a licensed clinician, or track your lab history and health goals in Aumnivida.

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