Antibody IgG

What the laboratory says this test is for

This immunodiffusion assay is highly specific for histoplasmosis infection but may have low sensitivity in early infection. Two different immunoprecipitin bands may be detected. The M band develops with acute infection, is often present in chronic infection, and may persist for months to years. The H band, which is usually present with the M band, generally suggests a chronic or severe acute infection. The presence of both the H and M bands is considered conclusive for the diagnosis of histoplasmosis.

What the laboratory says this test is for

This panel may be used as an aid in the diagnosis of several fungal infections that can cause serious infection. This qualitative immunodiffusion-based test is designed to detect serum antibodies directed against Aspergillus species (specifically A. flavus, A. fumigatus, A. niger), Blastomyces dermatitidis, Candida species, Coccidioides immitis, and Histoplasma capsulatum.These fungi may cause invasive infections that can represent a diagnostic challenge. While the endemic mycoses may have differing epidemiological risk factors, clinically they may have overlapping features. Thus, definitive diagnosis depends on fungal culture, characteristic fungal staining in specimens, or other direct diagnostic means, such as molecular methods, that may require invasive procedures.Immunodiffusion bands of identity or partial identity with a positive control are considered positive and indicate patient antibody against the fungal antigen in question. Negative results do not rule out infection, especially if testing is done before antibody development early in infection or if the patient is immunocompromised. Test results should be correlated with the patient's epidemiological risk factors and clinical findings.

What the laboratory says this test is for

Echinococcus IgG detection is an important tool for diagnosing hydatid disease, since infected individuals do not exhibit fecal shedding of E. granulosus eggs.

What the laboratory says this test is for

This panel may provide antibody-based evidence of a recent or previous infection with Toxoplasma gondii, rubella virus, cytomegalovirus, and/or herpes simplex virus in pregnant individuals. This panel is generally ordered as part of a prenatal evaluation of a patient who is at risk of infection with these microbial agents. However, routine serology testing for these infections as a group has low diagnostic yield for non-specific ultrasound abnormalities of fetuses [1,2].Some maternal infections during pregnancy may be associated with miscarriage, stillbirth, or fetal abnormalities. These infections may be primary (ie, occur for the first time) or the result of reactivation of prior infections (eg, herpes simplex virus or cytomegalovirus). Infections with these pathogens may have a subclinical course in the mother and transmit to the infant during the prenatal or perinatal period [3].Testing for infections in pregnant persons should be guided by pathogen-specific clinical features, risk factors, and prevalence [1]. The American Academy of Pediatrics Committee on Fetus and Newborn and American College of Obstetricians and Gynecologists Committee on Obstetric Practice recommend serologic screening for evidence of rubella immunity at the first prenatal visit [3]. Routine serologic screening of pregnant individuals for Toxoplasma and cytomegalovirus is not recommended [3]. Type-specific serologic testing for herpes simplex virus may be useful in the evaluation of risk for infection or confirmation of suspected infection [3,4].This panel is not recommended for use in documenting newborn congenital infections. In this clinical situation, consider requesting the Torch Panel, Acute.The results of this test panel should be interpreted in the context of pertinent clinical findings.References1. Fitzpatrick D, et al. Prenat Diagn. 2022;42(1):87-96.2. Society for Maternal-Fetal Medicine (SMFM), et al. Am J Obstet Gynecol. 2020;223(4):B2-B17.3. American Academy of Pediatrics Committee on Fetus and Newborn and American College of Obstetricians and Gynecologists Committee on Obstetric Practice. Guidelines for Perinatal Care. 8th ed. 2017. Accessed April 28, 2022.4. Workowski KA, et al. MMWR Recomm Rep. 2021;70(4):1-187.

What the laboratory says this test is for

This panel is designed to assist in determining the causative agent in cases of suspected fungal-associated respiratory infections