5-HIAA, Urine, 24hr

Primary unit: mg/24 hr
LOINC codes: 1695-6
Tests that measure 5-HIAA, Urine, 24hr: Labcorp 1, Quest Diagnostics 1

Ranges

Each lab publishes a reference range for the population groups it tests, usually the middle 95% of results. These intervals describe that population, not an optimal or healthy target. How ranges differ

Quest Diagnostics, 5-Hydroxyindoleacetic Acid (5-HIAA), 24-Hour Urine without Creatinine 523

Population	Interval
<2 Years	Not established
2-10 Years	≤8.0 mg/24 h
>10 Years	≤6.0 mg/24 h

Quest Diagnostics test catalog, 523

Tests

Check the catalog code, specimen, method and preparation for every test that measures 5-HIAA, Urine, 24hr. Select up to five tests to compare them side by side.

Labcorp 1 test

Panels that include this biomarker

5-Hydroxyindoleacetic Acid (HIAA), Quantitative, 24-Hour Urine 004069
2 analytes · Urine · Fasting not stated · Turnaround 4 - 8 days
Method and collection
Method
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Preparation
Avoid bananas, avocados, plums, eggplant, tomatoes, avocados plums, eggplant, tomatoes, plantain, pineapple, walnuts, and interfering drugs for a 72 hour period prior to and during collection. Foods and medications associated with altered urinary HIAA results: Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, alcohol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), <isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®). Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
Collection
Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely. Label container with patient's name, date, and time. Measure and record total urine volume. Mix well; send aliquot.
Reference notes
0.0−14.9 mg/24 hours If a borderline elevation of 5-HIAA is found, sample should be recollected following withdrawal of dietary and medication sources that might elevate 5-HIAA (see Patient Preparation). Nontropical sprue may cause a slight increase in urinary 5-HIAA. 5-HIAA levels are lowered by renal insufficiency and after small bowel resection. When a patient strongly suspected for carcinoid syndrome shows normal or borderline increases of 5-HIAA, two possibilities should be considered: one, that large amounts of serotonin produced are not being metabolized, in which case blood levels of serotonin are required to document the diagnosis; and two, that secretion of 5-HIAA by the tumor is intermittent, in which case repeat timed specimen collections are needed to demonstrate the abnormality.
Labcorp catalog page

Quest Diagnostics 1 test

Single-analyte tests

5-Hydroxyindoleacetic Acid (5-HIAA), 24-Hour Urine without Creatinine 523
Urine · Fasting not stated · Turnaround Set up: Tues, Thurs, Fri (p.m.); Report available: 5 days
Method and collection
Method
High Performance Liquid Chromatography (HPLC)
Preparation
Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant
Collection
Collect 24-hour urine with 25 mL 6N HCl to maintain a pH ≤3. If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be ≤6. Record 24-hour urine volume and patient's age on test request form and urine container.
Quest Diagnostics catalog page

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Sources

Labcorp test catalog
1 test: codes, specimens, methods, preparation and reference intervals.
Quest Diagnostics test catalog
1 test: codes, specimens, methods, preparation and reference intervals.
LOINC 1695-6
Regenstrief Institute codes that identify the same result across labs.
Search ClinicalTrials.gov for 5-HIAA, Urine, 24hr
Registered studies that measure 5-HIAA, Urine, 24hr, on the U.S. National Library of Medicine registry.

Verify these ranges and sources

We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

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