Biomarker Lens

Goals and conditions

Start from what you want to check, such as iron deficiency or heart health, and find the primary and companion biomarkers a named guideline or study connects to it.

Health goals

  • Anemia

    A hemoglobin concentration below the level expected for age, sex and pregnancy status, from any cause.

    4 biomarkers

  • Blood sugar

    Average and fasting blood glucose as diabetes guidelines measure them for screening, diagnosis and treatment goals.

    2 biomarkers

  • Energy and fatigue

    The blood tests NICE uses to exclude other medical causes when debilitating, persistent fatigue suggests ME/CFS.

    13 biomarkers

  • Heart health

    Cardiovascular risk as lipid and inflammation guidelines assess it: the cholesterol-carrying lipoproteins, triglycerides and markers that refine risk.

    6 biomarkers

  • Inflammation

    Low-grade systemic inflammation as measured by high-sensitivity C-reactive protein for cardiovascular risk assessment.

    1 biomarker

  • Iron deficiency

    Low body iron stores, with or without anemia, as measured by serum ferritin and the related iron tests.

    3 biomarkers

  • Kidney function

    How well the kidneys filter blood and hold back protein, as kidney guidelines measure it with estimated GFR and urine albumin.

    4 biomarkers

  • Liver health

    Liver injury, bile flow and synthetic function as the common liver chemistry tests measure them.

    6 biomarkers

  • Male hormones

    Testosterone and the pituitary hormones that control it, as measured when male hypogonadism is evaluated.

    4 biomarkers

  • Thyroid function

    How much thyroid hormone the thyroid makes, as measured first by TSH and then by free thyroid hormones and antibodies.

    4 biomarkers

  • Vitamin B12 and folate

    Vitamin B12 and folate status, two B vitamins needed to make red blood cells and keep nerves working.

    4 biomarkers

  • Vitamin D and bone

    Vitamin D status for bone health, measured as serum 25-hydroxyvitamin D, with calcium and parathyroid hormone in context.

    3 biomarkers

Conditions

Each condition shows its ICD-10-CM code.

  • Celiac diseaseK90.0

    An immune reaction to gluten that damages the small intestine; diagnosis starts with blood antibody tests.

    4 biomarkers

  • Chronic kidney diseaseN18.9

    Abnormal kidney structure or function present for at least 3 months, staged by GFR category and albuminuria category.

    3 biomarkers

  • GoutM10.9

    Inflammatory arthritis caused by urate crystals; treatment guidelines set a serum urate target.

    1 biomarker

  • Hereditary hemochromatosisE83.110

    An inherited condition, most often from HFE gene variants, in which the body absorbs and stores too much iron.

    4 biomarkers

  • HypercholesterolemiaE78.00

    Raised blood cholesterol carried in LDL particles; LDL-C of 190 mg/dL or higher is classed as severe primary hypercholesterolemia.

    4 biomarkers

  • HyperthyroidismE05.90

    An overactive thyroid causing thyrotoxicosis, too much thyroid hormone in the body.

    3 biomarkers

  • HypothyroidismE03.9

    An underactive thyroid that makes too little thyroid hormone.

    3 biomarkers

  • Iron deficiency anemiaD50.9

    Anemia caused by too little iron to make hemoglobin; guidelines confirm iron deficiency with serum ferritin.

    2 biomarkers

  • Metabolic dysfunction-associated steatotic liver disease (MASLD)K76.0

    Fat in the liver together with at least one cardiometabolic risk factor, formerly called nonalcoholic fatty liver disease (NAFLD).

    7 biomarkers

  • Metabolic syndromeE88.810

    A cluster of five cardiometabolic risk factors (waist, triglycerides, HDL-C, blood pressure and fasting glucose); any three make the diagnosis.

    3 biomarkers

  • PrediabetesR73.03

    Blood glucose above normal but below the diabetes threshold, defined by A1C, fasting glucose or a glucose tolerance test.

    2 biomarkers

  • Type 2 diabetesE11.9

    Diabetes from progressive loss of insulin secretion, usually with insulin resistance, diagnosed by A1C or plasma glucose.

    4 biomarkers

  • Vitamin B12 deficiencyE53.8

    Too little vitamin B12 for normal blood cell production and nerve function, with or without anemia.

    2 biomarkers

  • Vitamin D deficiencyE55.9

    Low vitamin D status, assessed by serum 25-hydroxyvitamin D; the thresholds used to define it differ between guidelines.

    2 biomarkers