AD-Detect Beta-Amyloid 42/40 Ratio

Primary unit: Ratio
LOINC codes: 104166-4, 104663-0, 106941-8, 33200-7, 70073-2
Tests that measure AD-Detect Beta-Amyloid 42/40 Ratio: Quest Diagnostics 2

Ranges

Each lab publishes a reference range for the population groups it tests, usually the middle 95% of results. These intervals describe that population, not an optimal or healthy target. How ranges differ

Quest Diagnostics, AD-Detect® ABeta 42/40, p-tau217, and ApoE Evaluation, Plasma 16493

Population	Interval
ABeta 42	Not Established
ABeta 40	Not Established
ABeta 42/40 Ratio	≥0.170
AD Detect ptau217, Plasma	≤0.15 pg/mL
AD Detect® ApoE Isoform, Plasma	Not Established
AD Detect® Likelihood Score w/ApoE	Not stated
Likelihood of amyloid PET positivity	Not stated
Low Likelihood	<0.3714
Indeterminate	0.3714 to 0.5375
High Likelihood	>0.5375

Quest Diagnostics test catalog, 16493

Quest Diagnostics, AD-Detect™ ABeta 42/40 and p-tau217 Evaluation, Plasma 14258

Population	Interval
ABeta 42	Not Established
ABeta 40	Not Established
ABeta 42/40 Ratio	≥0.170
AD Detect p-tau217	≤0.15 pg/mL
AD Detect Likelihood Score	Not stated
Likelihood of amyloid PET positivity	Not stated
Low Likelihood	<0.3254
Indeterminate	0.3254-0.6460
High Likelihood	>0.6460

Quest Diagnostics test catalog, 14258

Tests

Check the catalog code, specimen, method and preparation for every test that measures AD-Detect Beta-Amyloid 42/40 Ratio. Select up to five tests to compare them side by side.

Quest Diagnostics 2 tests

Panels that include this biomarker

AD-Detect™ ABeta 42/40 and p-tau217 Evaluation, Plasma 14258
4 analytes · Plasma · Fasting not stated
Method and collection
Method
Immunoassay (IA) • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Preparation
Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample
Collection
Quest Diagnostics does not perform this test for individuals under the age of 18. Pre-test and post-test counseling is strongly recommended. Collect blood into a K2 EDTA (lavender-top) tube and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into 2 separate polypropylene tubes or 2 separate Quest issued polypropylene pour-off/transfer tubes. Do not transfer to conical tubes. Store frozen.
Quest Diagnostics catalog page
AD-Detect® ABeta 42/40, p-tau217, and ApoE Evaluation, Plasma 16493
5 analytes · Plasma · Fasting not stated
Method and collection
Method
Immunoassay (IA) • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Preparation
Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample
Collection
Quest Diagnostics does not recommend performing this test on individuals under the age of 18. Pre-test and post-test counseling is strongly recommended. Collect blood into two K2 EDTA plasma tubes and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into three separate polypropylene tubes or three separate Quest issued polypropylene pour-off/transfer tubes. Do not transfer to conical tubes. Store and ship frozen.
Quest Diagnostics catalog page

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Sources

Quest Diagnostics test catalog
2 tests: codes, specimens, methods, preparation and reference intervals.
LOINC 104166-4, 104663-0, 106941-8, 33200-7, 70073-2
Regenstrief Institute codes that identify the same result across labs.
Search ClinicalTrials.gov for AD-Detect Beta-Amyloid 42/40 Ratio
Registered studies that measure AD-Detect Beta-Amyloid 42/40 Ratio, on the U.S. National Library of Medicine registry.

Verify these ranges and sources

We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

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