Anticardiolipin Ab,IgA,Qn

Single-analyte tests

• Anticardiolipin Antibodies (ACA), IgA, Quantitative 161836

  Serum · Fasting not stated · Turnaround 2 - 4 days

  Method and collection

  Method

  Thermo Fisher EliA™ automated FEIA-based autoantibody test

  Reference notes

  Anticardiolipin Antibodies (ACA), IgA: 0.0–16.5 APL-U/mL

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Panels that include this biomarker

• Anticardiolipin Antibodies (ACA), IgA, IgG, IgM, Quantitative 161950

  3 analytes · Serum · Fasting not stated · Turnaround 2 - 4 days

  Method and collection

  Method

  Thermo Fisher EliA™ automated FEIA-based autoantibody test

  Reference notes

  Anticardiolipin Antibodies (ACA), IgA: 0.0–16.5 APL-U/mL Anticardiolipin Antibodies (ACA), IgG: 0.0–13.3 GPL-U/mL Anticardiolipin Antibodies (ACA), IgM: 0.0–29.4 MPL-U/mL

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• Lupus Prognostic Profile 520555

  9 analytes · Serum · Fasting not stated · Turnaround 7 - 10 days

  Method and collection

  Method

  ELISA

  Collection

  Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

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• Thrombotic Risk, Acquired 117145

  11 analytes · Serum · Fasting not stated · Turnaround 3 - 7 days

  Method and collection

  Method

  See individual tests.

  Preparation

  Do not draw from an arm with a heparin lock or heparinized catheter.

  Collection

  Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anti-coagulant with the blood. A discard tube is not required prior to collection of coagulation samples except when using a winged blood collection device (i.e., "butterfly"), in which case a discard tube should be used.4,5 When non-citrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap and recentifuge for 10 minutes. Use a second plastic pipette to remove plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested. It is important to centrifuge blood samples for plasma collection immediately after collection to separate the plasma from the blood cells. If immediate centrifugation is not possible, collected blood specimens should be kept on ice and centrifuged within an hour. Serum: If a red-top tube is used, transfer separate serum to a plastic transport tube. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.

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• ANA 12 Profile, Do All (RDL) 520299

  14 analytes · Serum · Fasting not stated · Turnaround 14 - 21 days

  Method and collection

  Method

  See individual test components.

  Collection

  Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

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• Antiphospholipid Syndrome (APS) Assessment 164535

  14 analytes · Serum · Fasting not stated · Turnaround 4 - 6 days

  Method and collection

  Method

  Clot-based assays for lupus anticoagulants and enzyme-linked immunoassays (ELISAs) for antiphospholipid antibodies

  Preparation

  Do not draw from an arm with a heparin lock or heparinized catheter.

  Collection

  Plasma: Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.26 Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio.27,28 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anti-coagulant with the blood. A discard tube is not required prior to collection of coagulation samples except when using a winged blood collection device (i.e., "butterfly"), in which case a discard tube should be used.29,30 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap and recentifuge for 10 minutes. Use a second plastic pipette to remove plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested . It is important to centrifuge blood samples for plasma collection immediately after collection to separate the plasma from the blood cells. If immediate centrifugation is not possible, collected blood specimens should be kept on ice and centrifuged within an hour. Serum: If a red-top tube is used, transfer separate serum to a plastic transport tube. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.

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Single-analyte tests

• Cardiolipin Antibody (IgA) 4661

  Plasma · Fasting not stated · Turnaround Set up: Mon-Fri (Day shift); Report available: 4 days

  Method and collection

  Method

  Immunoassay (IA)

  Quest Diagnostics catalog page

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Panels that include this biomarker

• Antiphospholipid Syndrome Diagnostic Panel 19872

  5 analytes · Plasma · Fasting not stated

  Method and collection

  Method

  Immunoassay (IA) • Photo-Optical Clot Detection

  Collection

  Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.

  Reference notes

  See individual tests

  Quest Diagnostics catalog page

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• Antiphospholipid Antibody Panel 14890

  6 analytes · Plasma · Fasting not stated

  Method and collection

  Method

  Immunoassay (IA)

  Collection

  Plasma (preferred): Centrifuge light blue-top tube 15 minutes at approximately 1500 x g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Serum: Centrifuge a red-top tube (no gel) or serum separator tube 15 minutes at approximately 1500 g within 24 hours of collection. Transfer serum into a plastic specimen vial.

  Reference notes

  See individual tests

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• Recurrent Miscarriage/Coagulation Panel with Reflex (without Consultation) 11469

  11 analytes · Plasma · Fasting not stated

  Method and collection

  Method

  Chromogenic Clotting Assay • Enzyme Immunoassay (EIA) • Immunoturbidimetric Immunoassay • Polymerase Chain Reaction and Detection

  Collection

  Whole blood sample is for the Factor V Mutation Analysis and Prothrombin (Factor II) Mutation Analysis. Platelet-poor plasma is for remaining tests. Platelet-poor plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 x g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into four plastic vials. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.

  Reference notes

  See Laboratory Report

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• Recurrent Miscarriage Evaluation/Coagulation Panel with Consultation 19671

  13 analytes · Serum · Fasting not stated

  Method and collection

  Method

  Chromogenic • Clotting Assay • Enzyme Immunoassay (EIA) • Immunoassay (IA) • Immunoturbidimetric • Polymerase Chain Reaction & Detection

  Collection

  Whole blood sample is for the Factor V Mutation Analysis and Prothrombin (Factor II) Mutation Analysis. Serum sample is for the Homocysteine. Red-top tubes: Place the specimen in a refrigerator or ice bath for 30 minutes after collection. Centrifuge the specimen as soon as possible after complete clot formation has taken place. Transfer the serum to a plastic screw-capped vial. Barrier gel separator tubes: Place the specimen in a refrigerator for 30 minutes after collection. Centrifuge the specimen as soon as possible after complete clot formation has taken place. Do not place barrier tubes in an ice bath as freezing may prevent the barrier gel from adequately separating serum from cells. Platelet-poor plasma is for remaining tests. Platelet-poor plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 x g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into four plastic vials. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice. Serum and plasma must remain frozen during storage and shipment. All requests for coagulation assays should include a brief patient history and other pertinent clinical information.

  Reference notes

  See Laboratory Report

  Quest Diagnostics catalog page

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• ANAlyzeR™ ANA, IFA with Reflex Titer/Pattern, Systemic Autoimmune Panel 1 36378

  19 analytes · Serum · Fasting not stated

  Method and collection

  Method

  See individual tests

  Preparation

  Overnight fasting is preferred

  Collection

  Draw three, full, 8.5 mL serum separator tubes. Allow the blood to clot for at least 30 minutes, but not longer than 1 hour before centrifugation. Centrifuge each tube for 15 minutes at 1250 to 1600 RCF. If drawn in red-top (no gel) tubes, transfer serum to transport tube(s). Place sample(s) on cold packs or in refrigerator. Sample is stable 4 days at 2-8° C (refrigerated).

  Reference notes

  See Laboratory Report

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