Collagen Binding Activity

Also listed as: CBA
Primary unit: %
LOINC codes: 50377-1
Tests that measure Collagen Binding Activity: Labcorp 1, Quest Diagnostics 1

Ranges

Each lab publishes a reference range for the population groups it tests, usually the middle 95% of results. These intervals describe that population, not an optimal or healthy target. How ranges differ

Quest Diagnostics, von Willebrand Factor Collagen Binding Assay 10924

Population	Interval
vWf:Collagen Binding	45-198 %normal
Ratio (CBA/vW Ag)	≥0.50 ratio

Quest Diagnostics test catalog, 10924

Tests

Check the catalog code, specimen, method and preparation for every test that measures Collagen Binding Activity. Select up to five tests to compare them side by side.

Labcorp 1 test

Panels that include this biomarker

von Willebrand Factor (vWF) Collagen-Binding Activity (CBA) 117169
3 analytes · Plasma · Fasting not stated · Turnaround 5 - 9 days
Method and collection
Method
The VWF:CB assay tests the capacity of plasma VWF to bind collagen. Human Type III collagen is used. After plasma sample incubation with the collagen, residual unbound proteins are removed by washing procedures. The bound VWF is detected with anti-VWF antibodies and an assay-specific detection system.
Collection
Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.25 Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio.26,27 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples unless the sample is collected using a winged (butterfly) collection system. With a winged blood collection set, a discard tube should be drawn first to account for the dead space of the tubing and prevent under-filling of the evacuated tube.28,29 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternative anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
Reference notes
CBA activity: 50% to 150% CBA ratio: 0.6−5.0 vWF antigen: 50% to 150%
Labcorp catalog page

Quest Diagnostics 1 test

Panels that include this biomarker

von Willebrand Factor Collagen Binding Assay 10924
2 analytes · Plasma · Fasting not stated · Turnaround Set up: Wed, Fri
Method and collection
Method
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Quest Diagnostics catalog page

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Sources

Labcorp test catalog
1 test: codes, specimens, methods, preparation and reference intervals.
Quest Diagnostics test catalog
1 test: codes, specimens, methods, preparation and reference intervals.
LOINC 50377-1
Regenstrief Institute codes that identify the same result across labs.
Search ClinicalTrials.gov for Collagen Binding Activity
Registered studies that measure Collagen Binding Activity, on the U.S. National Library of Medicine registry.

Verify these ranges and sources

We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

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