Epinephrine, Urine

Panels that include this biomarker

• Catecholamines, Fractionated, Urinary Free, 24-Hour Urine 004176

  5 analytes · Urine · Fasting not stated · Turnaround 4 - 7 days

  Method and collection

  Method

  Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

  Preparation

  Avoid patient stress. Many drugs (reserpine and α-methyldopa, levodopa, monoamine oxidase inhibitors, and sympathomimetic amines) may interfere and should be discontinued two weeks prior to specimen collection. Nose drops, sinus and cough medicines, bronchodilators and appetite suppressants, α2-agonists, calcium channel blockers, converting enzyme inhibitors, bromocriptine, phenothiazine, tricyclic antidepressants, α- and β-blockers, and labetalol may interfere.1 Mandelamine® interferes, but thiazides do not. Caffeine products should be avoided before and during collection. The patient should not be subjected to hypoglycemia or exertion. Increased intracranial pressure and clonidine withdrawal can cause false-positive results.1,2

  Collection

  Instruct the patient to void at 8 a.m. and discard the specimen. Preservative must be added to the container prior to the start of collection. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (i.e., 8 a.m. the next morning). Label container. Keep collection on ice. Measure and record total urine volume on the test request form. Remove 20 mL aliquot. pH should be <5. Refer to the Preservative Quick Reference Chart in Specimen Collection: Urine Specimens .

  Reference notes

  Adults: • Epinephrine: − 0 to 9 years: 0−11 μg/24 hours − 10 to 19 years: 0−18 μg/24 hours − >19 years: 0−20 μg/24 hours • Norepinephrine: − 0 to 9 years: 0−59 μg/24 hours − 10 to 19 years: 0−90 μg/24 hours − >19 years: 0−135 μg/24 hours • Dopamine: − 0 to 9 years: 0−414 μg/24 hours − 10 to 19 years: 0−575 μg/24 hours − >19 years: 0−510 μg/24 hours

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• Catecholamines, Fractionated, Urinary Free, Random Urine 316203

  5 analytes · Urine · Fasting not stated · Turnaround 5 - 9 days

  Method and collection

  Method

  Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

  Preparation

  Avoid patient stress. Many drugs (reserpine and alpha methyldopa, levodopa, monoamine oxidase inhibitors, and sympathomimetic amines) may interfere and should be discontinued two weeks prior to specimen collection. Nose drops, sinus and cough medicines, bronchodilators and appetite suppressants, α2-agonists, calcium channel blockers, converting enzyme inhibitors, bromocriptine, phenothiazine, tricyclic antidepressants, α- and β-blockers, and labetalol may interfere.1 Mandelamine® interferes, but thiazides do not. Caffeine products should be avoided before and during collection. The patient should not be subjected to hypoglycemia or exertion. Increased intracranial pressure and clonidine withdrawal can cause false-positive results.1,2

  Collection

  Refer to the Preservative Quick Reference Chart in Specimen Collection: Urine Specimens .

  Reference notes

  Pediatric3 and adults: • Epinephrine: − 0 to 9 years: 0−37 μg/g creatinine − 10 to 19 years: 0−17 μg/g creatinine − >19 years: 0−19 μg/g creatinine • Norepinephrine: − 0 to 9 years: 0−150 μg/g creatinine − 10 to 19 years: 0−67 μg/g creatinine − >19 years: 0−111 μg/g creatinine • Dopamine: − 0 to 9 years: <1488 μg/g creatinine − 10 to 19 years: <354 μg/g creatinine − >19 years: <348 μg/g creatinine

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• Catecholamines, Fractionated, Urinary Free and Vanillylmandelic Acid (VMA), 24-Hour Urine 286161

  7 analytes · Urine · Fasting not stated · Turnaround 6 - 9 days

  Method and collection

  Method

  Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

  Preparation

  See Catecholamines, Fractionated, Urinary Free, 24-Hour Urine [004176] and Vanillylmandelic Acid (VMA), 24-Hour Urine [004143] .

  Collection

  Preservative must be added to the container prior to the start of collection. Collect 24-hour urine. Mix well. Send 60 mL aliquot. Record total 24-hour urine volume on test request form. Final pH must be <5. Note: Do not use boric acid or acetic acid as a preservative. Refer to the Preservative Quick Reference Chart in Specimen Collection: Urine Specimens .

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Panels that include this biomarker

• Catecholamines, Fractionated, Random Urine 5244

  4 analytes · Urine · Fasting not stated · Turnaround Set up: Mon-Fri p.m.

  Method and collection

  Method

  Liquid Chromatography/Mass Spectrometry (LC/MS)

  Preparation

  It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise for 8-12 hours prior to collection.

  Reference notes

  See Laboratory Report

  Quest Diagnostics catalog page

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