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Biomarkers · Chemical

Estradiol

An estrogen test measures the level of estrogens in a sample of your blood, urine (pee), or saliva (spit).

Estrogen Levels Test, MedlinePlus, National Library of Medicine

Also listed as
estrogen, e2, Estrogens, Total
Primary unit
pg/mL
LOINC codes
35384-7, 2254-1, 2243-4
Tests that measure Estradiol
Labcorp 10, Quest Diagnostics 9

Ranges

Each lab publishes a reference range for the population groups it tests, usually the middle 95% of results. These intervals describe that population, not an optimal or healthy target. How ranges differ

Quest Diagnostics, Estradiol, Ultrasensitive, LC/MS 30289

<1 yearNot EstablishedNot Established
Luteal Phase48-440 pg/mL
15-17 years≤31≤283
12-14 years≤24≤142
10-11 years≤12≤65
1-9 years≤4≤16
Pre-pubertal
AgeMales (pg/mL)Females (pg/mL)
Postmenopausal Phase≤10 pg/mL
Follicular Phase39-375 pg/mL
FemalesNot stated
Males≤29 pg/mL

Quest Diagnostics test catalog, 30289

Quest Diagnostics, Estrogens, Total, Immunoassay 439

PopulationInterval
FemaleNot stated
Male≤404 pg/mL
Postmenopausal≤214 pg/mL
Luteal Phase87-1194 pg/mL
Follicular Phase51-601 pg/mL

Quest Diagnostics test catalog, 439

Tests

Check the catalog code, specimen, method and preparation for every test that measures Estradiol. Select up to five tests to compare them side by side.

Labcorp 10 tests

Single-analyte tests

  • Estradiol 004515

    Serum · Fasting not stated · Turnaround Within 1 day

    Method and collection
    Method
    Electrochemiluminescence immunoassay (ECLIA) This assay is performed on the Roche cobas instrument in multiple laboratories throughout Labcorp.
    Collection
    If a red-top tube or plasma is used, transfer separated serum or plasma to a plastic transport tube.
    Reference notes
    • Adult male: 7.6−42.6 pg/mL • Adult female: − Follicular: 12.5−166.0 pg/mL − Ovulation: 85.8−498.0 pg/mL − Luteal: 43.8−211.0 pg/mL − Postmenopausal: <6.0−54.7 pg/mL • Pregnancy: First trimester: 215.0 to >4300.0 pg/mL • Children (1 to 10 years): − Male: 0.0−20.0 pg/mL − Female: 6.0−27.0 pg/mL Note: The results displayed above were obtained with the Roche ECLIA methodology.
    Labcorp catalog page

  • Estradiol, LC/MS (Endocrine Sciences) 500108

    Serum · Fasting not stated · Turnaround 6 - 10 days

    Method and collection
    Method
    Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
    Collection
    Serum/plasma must be separated from cells within 45 minutes of venipuncture. Send serum/plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested .
    Labcorp catalog page

  • Estradiol, Sensitive, LC/MS 140244

    Serum · Fasting not stated · Turnaround 3 - 6 days

    Method and collection
    Method
    Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
    Collection
    If a red-top tube is used, transfer separated serum to a plastic transport tube.
    Reference notes
    No patient age and/or gender provided. Newborn: Levels are markedly elevated at birth and fall rapidly during the first week to prepubertal levels <15.0 pg/mL. 1 to 6 months: Male: Levels increase to 10.0−32.0 pg/mL between 30 and 60 days, then decline to prepubertal levels <15.0 pg/mL by six months. 1 to 11 months: Female: Levels increase to 5.0−50.0 pg/mL between 30 and 60 days, then decline to prepubertal levels <15.0 pg/mL by the first year. Prepubertal children: • Male (6 months to 10 years): <15.0 • Female (1 to 9 years): <15.0 Puberty: See table. Tanner Stage Age (y) Range (pg/mL) Mean (pg/mL) Male 1 <9.8 5.0−11.0 8.0 2 9.8−14.5 5.0−16.0 11.0 3 10.7−15.4 5.0−25.0 16.0 4 11.8−16.2 10.0−36.0 22.0 5 12.8−17.3 10.0−36.0 21.0 Female 1 <9.2 5.0−20.0 8.0 2 9.2−13.7 10.0−24.0 16.0 3 10.0−14.4 7.0−60.0 25.0 4 10.7−15.6 21.0−85.0 47.0 5 11.8−18.6 34.0−170.0 110.0 Adults Range (pg/mL) Male 8.0−35.0 Female Follicular 30.0−100.0 Luteal 70.0−300.0 Postmenopausal <15.0
    Labcorp catalog page

  • Estrogens, Total 004549

    Serum · Fasting not stated · Turnaround 1 - 4 days

    Method and collection
    Method
    Enzyme-linked immunoassay (ELISA)
    Collection
    If tube other than a gel-barrier tube is used, transfer separated serum to a plastic transport tube.
    Reference notes
    See table.1 Age Male (pg/mL) Female (pg/mL) Prepubertal <40 <40 Adults 56−213 Female Cycle: 1 to 10 d: 16−328 11 to 20 d: 34−501 21 to 30 d: 48–350 Post-menopausal: 40–244
    Labcorp catalog page

Panels that include this biomarker

  • Estradiol Free, Equilibrium Dialysis, With Total Estradiol, HPLC/MS-MS (Endocrine Sciences) 500649

    3 analytes · Serum · Fasting not stated · Turnaround 9 - 12 days

    Method and collection
    Method
    Liquid chromatography tandem mass spectrometry (LC/MS/MS); equilibrium dialysis
    Collection
    Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested .
    Labcorp catalog page

  • ReproSURE™ (Ovarian Reserve Profile) 504295

    3 analytes · Serum · Fasting not stated · Turnaround 7 - 14 days

    Method and collection
    Method
    Anti-Müllerian Hormone: Electrochemiluminescence; FSH: Electrochemiluminescence; Estradiol: LC-MS/MS
    Collection
    Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection.
    Labcorp catalog page

  • Amenorrhea Profile (Endocrine Sciences) 501064

    4 analytes · Serum · Fasting not stated · Turnaround 7 - 15 days

    Method and collection
    Method
    See individual assays.
    Collection
    Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested .
    Labcorp catalog page

  • Menopausal Transition Profile I−Postmenopausal (Endocrine Sciences) 501218

    4 analytes · Serum · Fasting not stated · Turnaround 6 - 10 days

    Method and collection
    Method
    See individual assays.
    Collection
    Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested .
    Labcorp catalog page

  • Ovarian Function Profile II 244004

    7 analytes · Serum · Fasting not stated · Turnaround Within 1 day

    Method and collection
    Method
    See individual tests.
    Collection
    If a red-top tube is used, transfer separated serum to a plastic transport tube.
    Labcorp catalog page

Quest Diagnostics 9 tests

Single-analyte tests

  • Estradiol 4021

    Serum · Fasting not stated · Turnaround Set up: Mon-Sat (Day shift); Report available: 3 days

    Method and collection
    Method
    Immunoassay (IA)
    Collection
    Note: For any patients for whom low estradiol levels are anticipated (e.g. males, pre-pubertal children and hypogonadal/post-menopausal females), the Quest Diagnostics Estradiol, Ultrasensitive, LC/MS/MS assay is recommended (test code 30289). ⁠⁠⁠⁠⁠⁠⁠Do not add on estradiol testing to a barrier gel specimen older than 72 hours. Estradiol binds to barrier gel causing decreased values.
    Reference notes
    Female Follicular Phase | 30-144 pg/mL Mid-Cycle | 64-357 pg/mL Luteal Phase | 56-214 pg/mL Postmenopausal | ≤31 pg/mL Male | ≤39 pg/mL
    Quest Diagnostics catalog page

  • Estradiol, Ultrasensitive, LC/MS 30289

    Serum · Fasting not stated · Turnaround Set up: Mon-Sat; Report available: 5 days

    Method and collection
    Method
    Chromatography/Mass Spectrometry
    Collection
    Specify age and sex on test request form
    Quest Diagnostics catalog page

  • Estrogens, Total, Immunoassay 439

    Serum · Fasting not stated · Turnaround Set up: Mon-Sat (a.m.); Report available: 4 days

    Method and collection
    Method
    Enzyme Linked Immunosorbent Assay (ELISA)
    Collection
    Note: The stability study demonstrated a sharp decrease after 4 days at room temperature, which increases the risk of rejection if not shipped refrigerated. The total estrogens assay is not recommended for use in pre-pubertal children.
    Quest Diagnostics catalog page

Panels that include this biomarker

  • Estradiol and Estrone 7437

    3 analytes · Serum · Fasting not stated

    Method and collection
    Method
    Chromatography/Mass Spectrometry
    Collection
    Specify age and sex on test request form
    Reference notes
    See individual tests
    Quest Diagnostics catalog page

  • Estradiol, Free 36169

    4 analytes · Serum · Fasting not stated · Turnaround Set up: Wed, 1st and 3rd of each month (p.m.); Report available: 10 days

    Method and collection
    Method
    Chromatography/Mass Spectrometry • Equilibrium Dialysis
    Collection
    Specify age and sex on test requisition
    Reference notes
    See Laboratory Report
    Quest Diagnostics catalog page

  • Estrogens, Fractionated, LC/MS 36742

    5 analytes · Serum · Fasting not stated

    Method and collection
    Method
    Chromatography/Mass Spectrometry
    Collection
    Specify age and sex on test requisition
    Reference notes
    See individual tests
    Quest Diagnostics catalog page

  • Ovarian Assessment Report (OBGYN Format) 14115

    5 analytes · Serum · Fasting not stated

    Method and collection
    Method
    Chemiluminescent Enzyme Immunoassay • Enzyme Linked Immunosorbent Assay (ELISA)
    Collection
    Collect blood specimens in serum separator tube (SST) and allow to clot. Spin, separate, and transfer to transport tube. Specimen may be submitted to lab, ambient, refrigerated, or frozen.
    Reference notes
    AMH Low | 0.0-<0.3 ng/mL Reduced | 0.3-<0.7 ng/mL Adequate | 0.7-3.5 ng/mL High | >3.5 ng/mL FSH Follicular Phase | 3.5-12.5 mIU/mL Ovulation Phase | 4.7-21.5 mIU/mL Post Menopausal | 25.8-134.8 mIU/mL Estradiol Follicular Phase | 20.5-62.8 pg/mL Ovulation Phase | 60.4-602.0 pg/mL Post Menopausal | <5.0-138.0 pg/mL LH Follicular Phase | 2.4-12.6 mIU/mL Ovulation Phase | 14.0-95.6 mIU/mL Post Menopausal | 7.7-58.5 mIU/mL Inhibin B Reduced | <64.0 pg/mL Adequate | 64.0-200.0 pg/mL
    Quest Diagnostics catalog page

  • Ovarian Assessment Report (REI Format) 14116

    5 analytes · Serum · Fasting not stated

    Method and collection
    Method
    Chemiluminescent Enzyme Immunoassay • Enzyme Linked Immunosorbent Assay (ELISA)
    Collection
    Collect blood specimens in serum separator tube (SST) and allow to clot. Spin, separate, and transfer to transport tube. Specimen may be submitted to lab, ambient, refrigerated, or frozen.
    Reference notes
    AMH Low | 0.0-<0.3 ng/mL Reduced | 0.3-<0.7 ng/mL Adequate | 0.7-3.5 ng/mL High | >3.5 ng/mL FSH Follicular Phase | 3.5-12.5 mIU/mL Ovulation Phase | 4.7-21.5 mIU/mL Post Menopausal | 25.8-134.8 mIU/mL Estradiol Follicular Phase | 20.5-62.8 pg/mL Ovulation Phase | 60.4-602.0 pg/mL Post Menopausal | <5.0-138.0 pg/mL LH Follicular Phase | 2.4-12.6 mIU/mL Ovulation Phase | 14.0-95.6 mIU/mL Post Menopausal | 7.7-58.5 mIU/mL Inhibin B Reduced | <64.0 pg/mL Adequate | 64.0-200.0 pg/mL
    Quest Diagnostics catalog page

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Sources

Verify these ranges and sources

We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

Interpret your own results with a licensed clinician, or track your lab history and health goals in Aumnivida.

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