Normetanephrine

Panels that include this biomarker

• Metanephrines, Fractionated, Plasma Free 121806

  2 analytes · Plasma · Fasting not stated · Turnaround 3 - 6 days

  Method and collection

  Method

  Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

  Preparation

  Patient should be fasting overnight (water and non-caffeinated soft drinks are permissible). Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection. See Limitations section for more information about other potential causes of elevated metanephrines.

  Collection

  Draw blood in chilled lavender-top (EDTA) tube. Invert to mix with preservatives. Centrifuge and transfer the plasma to a labeled plastic transport tube. Refrigerate or freeze separated plasma immediately. Important: The patient should be in a fully recumbent position (lying down) for at least 20 minutes before and during sample collection.

  Reference notes

  Metanephrine, Pl Age | Male | Female All ages | 0.0–88.0 | 0.0–88.0 Normetanephrine, Pl Age | Male | Female 0 to 4 y | Not established | Not established 5 to 11 y | 0.0–165.9 | 0.0–148.0 12 to 19 y | 0.0–150.8 | 0.0–150.8 20 to 40 y | 0.0–210.1 | 0.0–210.1 41 to 50 y | 0.0–218.9 | 0.0–218.9 51 to 60 y | 0.0–244.0 | 0–244.0 61 to 80 y | 0.0–285.2 | 0.0–285.2 >80 y | 0.0–297.2 | 0.0–297.2 Adult reference intervals applied to free metanephrines were originally developed by Eisenhofer and coworkers10 and further validated in subsequent studies.11,12 Recognizing the potential deadly consequences of a missed diagnosis, cutoffs of reference were established to ensure optimum diagnostic sensitivity, with specificity a secondary consideration. Subjects fasted and abstained from caffeinated and decaffeinated beverages overnight. Plasma samples collected after at least 20 minutes of supine rest. For plasma metabolites, optimal performance was obtained using age-specific reference intervals for normetanephrine,10,11 and for metanephrine single cut-offs for males and females that were slightly above 99.5 percentiles contributed to optimized performance.11,12

  Labcorp catalog page

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Panels that include this biomarker

• Metanephrines, Fractionated, Free, LC/MS/MS, Plasma 19548

  3 analytes · Plasma · Fasting not stated · Turnaround Set up: Mon-Sat (p.m.); Report available: 5-6 days

  Method and collection

  Method

  Chromatography/Mass Spectrometry

  Preparation

  Patients should be relaxed in either a supine or upright position before blood is drawn. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection. Overnight fasting is preferred.

  Collection

  Draw specimen in a pre-chilled EDTA lavender-top Vacutainer™. The whole blood sample should be kept on wet ice until centrifuged (preferably at 4° C) to separate the plasma within 2 hours of venipuncture. After centrifugation, the plasma should be transferred to a transport tube and immediately refrigerated.

  Quest Diagnostics catalog page

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