RAS Mutation Analysis

LOINC codes: 21698-6, 21702-6, 21719-0, 31208-2, 53844-7
Tests that measure RAS Mutation Analysis: Quest Diagnostics 2

Ranges

Each lab publishes a reference range for the population groups it tests, usually the middle 95% of results. These intervals describe that population, not an optimal or healthy target. How ranges differ

Quest Diagnostics, Thyroid Cancer Mutation Panel 90469

Population	Interval
BRAF Mutation Analysis, Papillary Thyroid Cancer, BRAF Mutation	Not detected
RAS Mutation Analysis, Thyroid Cancer, HRAS Mutation	Not detected
RAS Mutation Analysis, Thyroid Cancer, KRAS Mutation	Not detected
RAS Mutation Analysis, Thyroid Cancer, NRAS Mutation	Not detected
RET/PTC Rearrangement, Thyroid Cancer, RETPTC1	Not detected
RET/PTC Rearrangement, Thyroid Cancer, RETPTC3	Not detected
PAX8/PPAR[gamma] Translocation, Thyroid Cancer, PAX8/PPAR	Not detected

Quest Diagnostics test catalog, 90469

Tests

Check the catalog code, specimen, method and preparation for every test that measures RAS Mutation Analysis. Select up to five tests to compare them side by side.

Quest Diagnostics 2 tests

Panels that include this biomarker

Thyroid Cancer Mutation Panel 90469
6 analytes · Tissue · Fasting not stated
Method and collection
Method
See individual tests
Collection
Do not reject. Needle washings in alcohol-based fixative (e.g. Cytolyt ®) or formalin-fixed, paraffin-embedded tissue block FNA or FFPE specimens are acceptable for the assay. All specimens must be accompanied with pathology report. All FFPE specimens will be examined by a pathologist for confirmation and adequacy. Macrodissection, if warranted, is performed in the lab.
Quest Diagnostics catalog page
Thyroid, FNA Cytomorphology with Molecular Reflex 90818
12 analytes · Needle washings in alcohol-based preservative (e.g. CytoLyt®) · Fasting not stated · Turnaround Set up: Mon-Fri (a.m.)
Method and collection
Method
Cytomorphology Review • Reflex: Polymerase Chain Reaction-based Molecular Testing
Collection
⁠⁠⁠⁠⁠⁠⁠DO NOT REJECT. Express a small portion of the FNA from needle directly onto glass slide and air dry or fix immediately by immersing in alcohol or by fixing with a commercially prepared cytology spray fixative. Label each slide with patient's name, pathology sample ID, and the number of needle pass (i.e., 1 for 1st, 2 for 2nd, etc). The needle should then be washed in a screw-cap vial of alcohol-based fixative (e.g. CytoLyt®) and labeled with patient's name, pathology sample ID and FNA location. FNAs from different locations (e.g., distinct nodules) should be collected individually on different slides and needle washings (e.g., A-left lobe, B-right lobe).
Reference notes
See Laboratory Report
Quest Diagnostics catalog page

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Sources

Quest Diagnostics test catalog
2 tests: codes, specimens, methods, preparation and reference intervals.
LOINC 21698-6, 21702-6, 21719-0, 31208-2, 53844-7
Regenstrief Institute codes that identify the same result across labs.
Search ClinicalTrials.gov for RAS Mutation Analysis
Registered studies that measure RAS Mutation Analysis, on the U.S. National Library of Medicine registry.

Verify these ranges and sources

We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

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