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  • Ferritin
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Biomarkers · Chemical

Tissue Plasminogen Activator

Also listed as
TPA
Primary unit
ng/mL
LOINC codes
5971-7
Tests that measure Tissue Plasminogen Activator
Labcorp 2

Tests

Check the catalog code, specimen, method and preparation for every test that measures Tissue Plasminogen Activator. Select up to five tests to compare them side by side.

Labcorp 2 tests

Single-analyte tests

  • Tissue Plasminogen Activator (tPA) Antigen 146010

    Plasma · Fasting not stated · Turnaround 5 - 8 days

    Method and collection
    Method
    Enzyme-linked immunosorbent assay (ELISA)
    Collection
    Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.24 Evacuated collection tubes must be filled to completion to ensure a proper blood-to anticoagulant ratio.25,26 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples unless the sample is collected using a winged (butterfly) collection system. With a winged blood collection set, a discard tube should be drawn first to account for the dead space of the tubing and prevent under-filling of the evacuated tube.27,28 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternative anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Double centrifugation is required for this test to ensure the removal of platelets that contain fibrinolysis factors.29,30 Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and re-centrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
    Reference notes
    0.0–12.0 ng/mL
    Labcorp catalog page

Panels that include this biomarker

  • Fibrinolysis Profile 117310

    7 analytes · Plasma · Fasting not stated · Turnaround 5 - 8 days

    Method and collection
    Method
    See individual tests.
    Collection
    Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.27 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.28,29 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples.30,31 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Double centrifugation is required for this test to ensure the removal of platelets that contain fibrinolysis factors.32,33 Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
    Labcorp catalog page

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Sources

Verify these ranges and sources

We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

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