Aldos/Renin Ratio

Panels that include this biomarker

• Aldosterone:Renin Ratio 004354

  3 analytes · Serum · Fasting not stated · Turnaround 4 - 7 days

  Method and collection

  Method

  Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

  Preparation

  Patients should be instructed to maintain an unrestricted dietary salt intake prior to testing. Washout of all interfering antihypertensive medications may be considered in patients with mild hypertension but is potentially problematic in others and perhaps unnecessary in that medications with minimal effect on the ARR can be used in their place. The patient should not take drugs that markedly affect the ARR for at least four weeks prior to blood collection. These drugs include: • Spironolactone, eplerenone, amiloride, and triamterene • Potassium-wasting diuretics • Products derived from licorice root (e.g., confectionary licorice, chewing tobacco) More details can be found in the Endocrine Society clinical practice guideline.1

  Collection

  Collect blood mid-morning, after the patient has been up (sitting, standing, or walking) for at least two hours and seated for 5 to 15 minutes. Refer to descriptions for individual tests Renin Activity, Plasma [002006] and Aldosterone, LC/MS [004374] for more detailed preparation and test collection information. After collection, immediately centrifuge the lavender-top tube at room temperature, transfer plasma to a transport tube, and freeze . Label this tube "Frozen Plasma−Renin." If a red-top tube is used, transfer separated serum to a plastic transport tube. Label the serum tube "Serum−Aldosterone." To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

  Reference notes

  0.0−30.0 ng/dL per ng/mL/hour

  Labcorp catalog page

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