Biomarkers · Chemical
C-Reactive Protein, Cardiac
A c-reactive protein test measures the level of c-reactive protein (CRP) in a sample of your blood. Your liver makes CRP in response to inflammation.
C-Reactive Protein (CRP) Test, MedlinePlus, National Library of Medicine
- Primary unit
- mg/L
- LOINC codes
- 30522-7
- Tests that measure C-Reactive Protein, Cardiac
- Quest Diagnostics 3, Labcorp 2
Ranges
Compare the reference ranges labs publish with guideline targets, diagnostic cut-offs, study-based ranges and practitioner targets. Move across the rows to check a value against each range, and open a source from the legend. How to read these ranges
C-Reactive Protein, Cardiac, mg/L
- Lab reference ranges2 labs
- Diagnostic cut-offs4 cut-offs
All 6 published ranges, with sources
Lab reference ranges
Quest, adults over 17below 1 mg/L
Adults over 17
Quest prints the AHA/CDC relative risk categories: below 1.0, 1.0 to 3.0 and 3.1 to 10.0 mg/L.
Labcorp, adultsbelow 1 mg/L
Adults
Labcorp prints risk categories rather than a statistical interval: low below 1.00, average 1.00 to 3.00, high above 3.00 mg/L.
Diagnostic cut-offs
CDC/AHA 2003, lower relative riskbelow 1 mg/L
Adults
Below 1.0 mg/L is the low relative risk category (approximate population tertiles).
CDC/AHA 2003, average relative risk1 to 3 mg/L
Adults
CDC/AHA 2003, higher relative risk3 mg/L and above
Adults
Above 3.0 mg/L; above 10 mg/L the statement advises repeating the test and looking for infection or inflammation.
AHA/ACC 2018 risk-enhancing factor2 mg/L and above
Adults in primary prevention
hs-CRP of 2.0 mg/L or higher is a risk-enhancing factor.
Tests
Check the catalog code, specimen, method and preparation for every test that measures C-Reactive Protein, Cardiac. Select up to five tests to compare them side by side.
Quest Diagnostics 3 tests
Single-analyte tests
Cardio IQ® hs-CRP 91737
Serum · Fasting not stated · Turnaround Set up: Mon-Fri
Quest Diagnostics catalog pageMethod and collection
- Method
- Immunoturbidimetric
- Reference notes
- ≤17 years Not established >17 years Optimal <1.0 mg/L Jellinger PS et al. Endocr Pract. 2017;23(Suppl 2):1-87. For ages >17 years hs-CRP (mg/L) Risk According to AHA/CDC Guidelines <1.0 Lower relative cardiovascular risk. 1.0-3.0 Average relative cardiovascular risk. 3.1-10.0 Higher relative cardiovascular risk. Consider retesting in 1 to 2 weeks to exclude a benign transient elevation in the baseline CRP value secondary to infection or inflammation. >10.0 Persistent elevation, upon retesting, may be associated with infection and inflammation.
hs-CRP 10124
Serum · Fasting not stated · Turnaround Set up: Mon-Fri (Night shift); Report available: 4 days
Quest Diagnostics catalog pageMethod and collection
- Method
- Immunoturbidimetric
- Reference notes
- ≤17 years | Not established >17 years | Optimal <1.0 mg/L Jellinger PS et al. Endocr Pract. 2017;23(Suppl 2):1-87. For ages >17 years hs-CRP (mg/L) | Risk According to AHA/CDC Guidelines <1.0 | Lower relative cardiovascular risk. 1.0-3.0 | Average relative cardiovascular risk. 3.1-10.0 | Higher relative cardiovascular risk. Consider retesting in 1 to 2 weeks to exclude a benign transient elevation in the baseline CRP value secondary to infection or inflammation. >10.0 | Persistent elevation, upon retesting, may be associated with infection and inflammation.
Panels that include this biomarker
Cognitive Assessment Panel with Reflex to T4 Free 18634
8 analytes · Serum · Fasting not stated
Quest Diagnostics catalog pageMethod and collection
- Method
- Spectrophotometry (SP) • Immunoturbidimetric • Enzymatic • Mass Spectrometry (MS) • Electronic Cell Sizing/Counting/Cytometry/Microscopy • Immunoassay (IA)
- Preparation
- Fasting is preferred Additional Considerations for Patient Preparation: Comprehensive Metabolic Panel: Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods. TSH: Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks after angiography. According to the assay manufacturer Siemens: samples containing fluorescein can produce falsely depressed values. Folate: Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
- Collection
- Serum for Homocysteine: Red-top tubes: Place the specimen in a refrigerator or ice bath for 30 minutes after collection. Centrifuge the specimen as soon as possible after complete clot formation has taken place. Transfer the serum to a plastic screw-capped vial. Barrier gel separator tubes: Place the specimen in a refrigerator for 30 minutes after collection. Centrifuge the specimen as soon as possible after complete clot formation has taken place. Do not place barrier tubes in an ice bath as freezing may prevent the barrier gel from adequately separating serum from cells. Serum for other tests, 3 SSTs: Collect using standard venipuncture techniques. Separate from clot as soon as possible after visible clot formation, usually 30 minutes after collection. Whole blood, 1 EDTA: Maintain specimen at room temperature. Do not refrigerate. If multiple draw, collect lavender-top tube last. Traumatic venipuncture tap can introduce thromboplastin and trap white blood cells and platelets. Refrigeration can precipitate fibrin and trap white blood cells and platelets.
- Reference notes
- See Laboratory Report
Labcorp 2 tests
Single-analyte tests
C-Reactive Protein (CRP), High Sensitivity (Cardiac Risk Assessment) 120766
Serum · Fasting not stated · Turnaround Within 1 day
Labcorp catalog pageMethod and collection
- Method
- Immunochemiluminometric assay (ICMA)
- Collection
- Separate serum or plasma from cells within one hour of collection.
- Reference notes
- Average hs-CRP level:1 • Low risk: <1.00 mg/L • Average risk: 1.00−3.00 mg/L • High risk: >3.00 mg/L
Panels that include this biomarker
Heart Disease and Stroke Risk Profile 500140
4 analytes · Serum · Fasting not stated · Turnaround 2 - 5 days
Labcorp catalog pageMethod and collection
- Method
- See individual tests.
- Preparation
- Do not draw from an arm with a heparin lock or heparinized catheter.
- Collection
- Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device (ie, "butterfly"), in which case a discard tube should be used.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
0 of 5 tests selected
Pick one moreGoals and conditions
We link C-Reactive Protein, Cardiac to these goals and conditions from named guidelines and studies.
Heart healthGoal, companion marker
The ACC/AHA primary prevention guideline lists hs-CRP of 2.0 mg/L or higher as a risk-enhancing factor.
InflammationGoal, primary marker
The CDC/AHA statement defines low, average and high relative risk categories for hs-CRP.
Sources
2 tests: codes, specimens, methods, preparation and reference intervals.
Quest Diagnostics test catalog
3 tests: codes, specimens, methods, preparation and reference intervals.
Consensus statement: Inflammation (primary), Range: CDC/AHA 2003, average relative risk, Range: CDC/AHA 2003, higher relative risk, Range: CDC/AHA 2003, lower relative risk
Clinical guideline: Range: AHA/ACC 2018 risk-enhancing factor
Clinical guideline: Heart health (companion)
Laboratory catalog: Range: Labcorp, adults
Quest Diagnostics Test Directory, hs-CRP (10124), 2025
Laboratory catalog: Range: Quest, adults over 17
MedlinePlus, National Library of Medicine
The description at the top of this page.
LOINC 30522-7
Regenstrief Institute codes that identify the same result across labs.
Search ClinicalTrials.gov for C-Reactive Protein, Cardiac
Registered studies that measure C-Reactive Protein, Cardiac, on the U.S. National Library of Medicine registry.
Verify these ranges and sources
We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.
Interpret your own results with a licensed clinician, or track your lab history and health goals in Aumnivida.
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