Creatine Kinase,Total

Single-analyte tests

• Creatine Kinase (CK), Total 001362

  Serum · Fasting not stated · Turnaround Within 1 day

  Method and collection

  Method

  Kinetic − 340 nm spectrophotometric

  Preparation

  Avoid exercise before venipuncture. Increases may be anticipated in the immediate postoperative period following surgical procedures involving incision through muscle.

  Collection

  Separate serum or plasma from cells. Avoid prolonged contact of serum or plasma with red cells.

  Reference notes

  See table. Age Male (U/L) Female (U/L) 0 to 7 d 59−1111 55−777 8 to 30 d 51−168 37−151 1 m to 1 y 57−301 50−263 2 to 12 y 53−229 45−198 13 to 17 y 53−446 32−182 18 to 50 y 49−439 32−182 51 to 80 y 41–331 32–182 >80 y 30–208 26–161

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Panels that include this biomarker

• Creatine Kinase (CK), MB and Total 002311

  2 analytes · Serum · Fasting not stated · Turnaround 1 - 3 days

  Method and collection

  Method

  CK total: kinetic, 340 nm spectrophotometric; CK-MB: immunochemiluminometric assay (ICMA)

  Preparation

  CK is most commonly elevated in acute myocardial infarction (AMI) in which it has its greatest usefulness. Collection of specimen at onset of symptoms to establish baseline values is needed. A patient at onset of acute myocardial infarction (AMI) will have normal results, but some patients reach medical attention at or beyond CK peak. To support the diagnosis of AMI, three CK isoenzyme determinations have classically been recommended, one on admission, a second 12 hours after admission, a third 24 hours after admission. Another at 48 hours may be needed. CK-MB usually peaks between 15 and 20 hours after the onset of a myocardial infarction. Pappas summarizes current literature regarding timing as follows. In non-Q wave, incomplete occlusion, nontransmural MI, CK-MB peaks on the average 15 hours from onset. In Q wave (complete occlusion) (transmural) infarction, CK-MB average peak is 17 to 20 hours after onset of symptoms. He emphasizes the importance of a sample for CK-MB drawn 16 hours after onset.1 When increased CK-MB values have returned to normal, CK isoenzyme determinations are usually no longer required.

  Reference notes

  See tables. Total CK (U/L) Age Male Female 0 to 7 d 59-1111 55-777 8 to 30 d 51−168 37−151 1 m to 1 y 57−301 50−263 2 to 12 y 53−229 45−198 13 to 17 y 53−446 32−182 18 to 50 y 49−439 32−182 51 to 80 y 41–331 32–182 >80 y 30–208 26–161 CK-MB (ng/mL): Male: 0.0–10.4 Female: 0.0–5.3

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• Creatine Kinase (CK), Total Plus Isoenzymes 002154

  6 analytes · Serum · Fasting not stated · Turnaround 3 - 6 days

  Method and collection

  Method

  Total: kinetic; isoenzymes: agarose gel electrophoresis with densitometry

  Preparation

  CK is most commonly elevated in acute myocardial infarction (AMI) in which it has its greatest usefulness. Collection of specimen at onset of symptoms to establish baseline values is needed. A patient at onset of AMI will have normal results, but some patients reach medical attention at or beyond CK peak. To support the diagnosis of AMI, three CK isoenzyme determinations have classically been recommended, one on admission, a second 12 hours after admission, a third 24 hours after admission. Another at 48 hours may be needed. CK-MB usually peaks between 15 and 20 hours after the onset of a myocardial infarction. Pappas summarizes current literature regarding timing as follows. In non-Q wave, incomplete occlusion, nontransmural MI, CK-MB peaks on the average 15 hours from onset. In Q wave (complete occlusion) (transmural) infarction, CK-MB average peak is 17 to 20 hours after onset of symptoms. He emphasizes the importance of a sample for CK-MB drawn 16 hours after onset.1 When increased CK-MB values have returned to normal, CK isoenzyme determinations are usually no longer required.

  Collection

  Submit two separate serum aliquots. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

  Reference notes

  See tables. Total CK (U/L) Age | Male | Female 0 to 7 d | 59-1111 | 55-777 8 to 30 d | 51−168 | 37−151 1 m to 1 y | 57−301 | 50−263 2 to 12 y | 53−229 | 45−198 13 to 17 y | 53−446 | 32−182 18 to 50 y | 49−439 | 32−182 51 to 80 y | 41–331 | 32–182 >80 y | 30–208 | 26–161 CK Isoenzymes (Male/Female) Macro type 2 | Not observed CK-MM | 97% to 100% Macro type 1 | Not observed CK-MB | 0% to 3% CK-BB | 0%

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• Creatine Kinase (CK) and Lactate Dehydrogenase (LD), Totals and Isoenzymes 001859

  12 analytes · Serum · Fasting not stated · Turnaround 4 - 7 days

  Method and collection

  Method

  Total: kinetic; Isoenzymes: agarose gel electrophoresis with densitometry

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Single-analyte tests

• Creatine Kinase (CK), Total 374

  Serum · Fasting not stated · Turnaround Set up: Mon-Sat; Report available: 3 days

  Method and collection

  Method

  Spectrophotometry (SP)

  Collection

  If CK and CK Isoenzymes are ordered together, specimen must be submitted frozen

  Quest Diagnostics catalog page

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Panels that include this biomarker

• Creatine Kinase Isoenzymes (CK Isoenzymes) with Total CK 4451

  3 analytes · Serum · Fasting not stated

  Method and collection

  Method

  Electrophoresis • Enzymatic

  Collection

  Allow blood to clot at room temperature for 30 minutes. Centrifuge immediately to separate the serum from cells and pour serum into a plastic transport tube. If CK and CK isoenzymes are ordered together, specimen must be submitted frozen.

  Reference notes

  See Laboratory Report

  Quest Diagnostics catalog page

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• Post COVID-19 Rheumatological Panel 11457

  6 analytes · See individual tests · Fasting not stated

  Method and collection

  Method

  See individual tests

  Reference notes

  See individual tests

  Quest Diagnostics catalog page

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