Creatine Kinase, MB

Single-analyte tests

• Creatine Kinase (CK), MB 120816

  Serum · Fasting not stated · Turnaround 1 - 2 days

  Method and collection

  Method

  Electrochemiluminescence immunoassay (ECLIA)

  Preparation

  The MB isoenzyme of CK is most commonly elevated in acute myocardial infarction (AMI). In AMI, plasma CK-MB typically rises some four to six hours after the onset of chest pains, peaks within 12 to 24 hours, and returns to baseline levels within 24 to 48 hours. The pattern of serial CK-MB determinations is more informative than a single determination.

  Collection

  If a red-top tube is used, transfer separated serum to a plastic transport tube.

  Reference notes

  • Male: 0.0−10.4 ng/mL • Female: 0.0−5.3 ng/mL

  Labcorp catalog page

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Panels that include this biomarker

• Creatine Kinase (CK), MB and Total 002311

  2 analytes · Serum · Fasting not stated · Turnaround 1 - 3 days

  Method and collection

  Method

  CK total: kinetic, 340 nm spectrophotometric; CK-MB: immunochemiluminometric assay (ICMA)

  Preparation

  CK is most commonly elevated in acute myocardial infarction (AMI) in which it has its greatest usefulness. Collection of specimen at onset of symptoms to establish baseline values is needed. A patient at onset of acute myocardial infarction (AMI) will have normal results, but some patients reach medical attention at or beyond CK peak. To support the diagnosis of AMI, three CK isoenzyme determinations have classically been recommended, one on admission, a second 12 hours after admission, a third 24 hours after admission. Another at 48 hours may be needed. CK-MB usually peaks between 15 and 20 hours after the onset of a myocardial infarction. Pappas summarizes current literature regarding timing as follows. In non-Q wave, incomplete occlusion, nontransmural MI, CK-MB peaks on the average 15 hours from onset. In Q wave (complete occlusion) (transmural) infarction, CK-MB average peak is 17 to 20 hours after onset of symptoms. He emphasizes the importance of a sample for CK-MB drawn 16 hours after onset.1 When increased CK-MB values have returned to normal, CK isoenzyme determinations are usually no longer required.

  Reference notes

  See tables. Total CK (U/L) Age Male Female 0 to 7 d 59-1111 55-777 8 to 30 d 51−168 37−151 1 m to 1 y 57−301 50−263 2 to 12 y 53−229 45−198 13 to 17 y 53−446 32−182 18 to 50 y 49−439 32−182 51 to 80 y 41–331 32–182 >80 y 30–208 26–161 CK-MB (ng/mL): Male: 0.0–10.4 Female: 0.0–5.3

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Single-analyte tests

• CK-MB (CK-2) 17581

  Serum · Fasting not stated

  Method and collection

  Method

  Chemiluminescence (CL)

  Reference notes

  0-5.0 ng/mL

  Quest Diagnostics catalog page

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