Heptacarb(7-CP),24hr, Urine

Panels that include this biomarker

• Porphyrins, Fractionated, Quantitative, 24-Hour Urine 729

  8 analytes · Urine · Fasting not stated · Turnaround Set up: Sun, Tues-Fri; Report available: 7 days

  Method and collection

  Method

  High Performance Liquid Chromatography (HPLC)

  Collection

  24-hour urine collected with 5 grams of sodium carbonate, refrigerated and protected from light during collection is preferred. Collection with no preservative is acceptable, if properly refrigerated and light protected. 24-hour total volume must be provided on the test requisition.

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• Porphyrins, Fractionated, Quantitative and Porphobilinogen, 24-Hour Urine 17198

  11 analytes · Urine · Fasting not stated

  Method and collection

  Method

  High Performance Liquid Chromatography (HPLC) • Chromatography/Mass Spectrometry

  Collection

  24-hour urine, collection should be adjusted to a pH of 6-7 with 5 g sodium carbonate (Na2CO3). Add the sodium carbonate at the start of the collection. The urine should be refrigerated and protected from light during collection. Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. Twenty-four hour specimens should be refrigerated and protected from UV light during collection. PBG is most stable at pH 6-7, but samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.

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Panels that include this biomarker

• Porphyrins, Quantitative, 24-Hour Urine 003194

  12 analytes · Urine · Fasting not stated · Turnaround 3 - 7 days

  Method and collection

  Method

  High-pressure liquid chromatography (HPLC) with fluorometric detection

  Collection

  Instruct patient to void at 8 AM (or 8 PM) and discard the specimen. Then collect all the urine, including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM [or 8 PM] the following day). Mix well. Measure and record total urine volume on the test request form, along with the patient's name, date, and time collection started and finished. Transfer required aliquot into a LabCorp amber plastic transport tube with amber cap (LabCorp N° 23598). (If amber transport tubes are unavailable, cover transport tube completely, top and bottom, with aluminum foil. Identify specimen with patient's name directly on the amber transport tube and on the outside of the aluminum foil. Secure with tape.) Specimen must be kept refrigerated during transport.

  Reference notes

  • Coproporphyrin (CP) I: 0−24 μg/24 hours • Coproporphyrin (CP) III: 0−74 μg/24 hours • Heptacarboxylporphyrins (7-CP): 0−4 μg/24 hours • Hexacarboxylporphyrins (6-CP): 0−1 μg/24 hours • Pentacarboxylporphyrins (5-CP): 0−4 μg/24 hours • Uroporphyrins (UP): 0−24 μg/24 hours See table. Pattern of the Different Porphyrias Disease Uro Hepta Hexa Penta Copro I Copro III + = increased; ++ = strongly increased; n = normal; v = varies. Values from: Doss M. Porphyrinstoffwechsel. In: Greiling H, Gressner AM (Hrsg). Lehrbuch der Klinischen Chemie und Pathobiochemie. Dritte Auflage. Stuttgart, Germany: Schattauer Verlag. Values marked with * and ** respectively, are derived from: *Hindmarsh JT, Oliveras L, Greenway DC. Biochemical differentiation of the porphyrias. Clin Biochem. 1999 Nov; 32(8):609-619. **Elder GH, Smith SG, Smyth SJ. Laboratory investigation of the porphyrias. Ann Clin Biochem. 1990 Sep; 27(Pt 5):395-412. Porphyria cutanea tarda (PCT) ++ ++ + + +* +* Acute intermittent porphyria (AIP) ++ + + ++ +* ++* Porphyria variegata (VP) ++ + + ++ +* ++* Hereditary coproporphyria (CP) + + + ++ n* ++* Protoporphyria v n n v +* v Morbus Gunther ++ + + + ++** Porphobilinogen synthase deficiency + + + ++ ++

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