Biomarkers · Chemical
Protein S-Functional
- Primary unit
- %
- LOINC codes
- 27822-6
- Tests that measure Protein S-Functional
- Quest Diagnostics 4, Labcorp 2
Ranges
Each lab publishes a reference range for the population groups it tests, usually the middle 95% of results. These intervals describe that population, not an optimal or healthy target. How ranges differ
Labcorp, Protein S, Functional 164525
| Population | Interval |
|---|---|
| Age | Range |
| 1 d | 28–47% |
| 3 d | 33–67% |
| 1 to 11 m | 29–162% |
| 1 to 5 y | 67–136% |
| 6 to 10 y | 64–154% |
| 11 to 16 y | 65–140% |
| >16 y | 54–129% |
Tests
Check the catalog code, specimen, method and preparation for every test that measures Protein S-Functional. Select up to five tests to compare them side by side.
Quest Diagnostics 4 tests
Single-analyte tests
Protein S Activity 1779
Plasma · Fasting not stated · Turnaround Report available: 4 days
Quest Diagnostics catalog pageMethod and collection
- Method
- Clot Detection
- Collection
- Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/uL). Freeze immediately and ship on dry ice.
- Reference notes
- Male 70-150 % normal Female 60-140 % normal
Panels that include this biomarker
Protein C and Protein S, Functional 39457
2 analytes · Plasma · Fasting not stated
Quest Diagnostics catalog pageMethod and collection
- Method
- Clotting Assay
- Collection
- Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.
- Reference notes
- Protein C Activity 0-15 years | No reference range available ≥16 years | 70-180 % normal Protein S Activity Males | 70-150 % normal Females | 60-140 % normal
Protein S Activity, Antigen, Total and Free 93355
2 analytes · Plasma · Fasting not stated
Quest Diagnostics catalog pageMethod and collection
- Method
- Clotting Assay • Immunoturbidimetric Assay
- Collection
- Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.
- Reference notes
- See individual tests
Thrombosis Panel 11051
4 analytes · Plasma · Fasting not stated
Quest Diagnostics catalog pageMethod and collection
- Method
- Clotting Assay • Clot Detection • Chromogenic Substrate • RVVT-based Assay (Clot-based)
- Collection
- Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/uL) Freeze immediately and ship on dry ice.
- Reference notes
- See individual tests
Labcorp 2 tests
Single-analyte tests
Protein S, Functional 164525
Plasma · Fasting not stated · Turnaround 2 - 3 days
Labcorp catalog pageMethod and collection
- Method
- The patient plasma is added to PS-depleted normal plasma with normal levels of all factors but PS. The mixture is supplemented with excess aPC and factor V is then added. The extent of prolongation of the time to clot formation after calcium chloride is added is proportional to plasma PS activity.
- Preparation
- Avoid warfarin (Coumadin®) therapy for two weeks and heparin therapy for two days prior to the test. Do not draw from an arm with a heparin lock or heparinized catheter.
- Collection
- Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device (i.e., "butterfly"), in which case a discard tube should be used.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
Panels that include this biomarker
Protein S Deficiency Profile 117754
3 analytes · Plasma · Fasting not stated · Turnaround 2 - 3 days
Labcorp catalog pageMethod and collection
- Method
- Total PS and free PS antigen: Total PS and free PS antigens are measured by latex immunoassay (IA). PS activity: The patient plasma is added to PS-depleted normal plasma with normal levels of all factors but PS. The mixture is supplemented with excess aPC, and factor V is then added. The extent of prolongation of the time to clot formation after calcium chloride is added is proportional to plasma PS activity.
- Preparation
- Avoid warfarin (Coumadin®) therapy for two weeks and heparin therapy for two days prior to the test. Do not draw from an arm with a heparin lock or heparinized catheter.
- Collection
- Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device (ie, "butterfly"), in which case a discard tube should be used.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
0 of 5 tests selected
Pick one moreSources
2 tests: codes, specimens, methods, preparation and reference intervals.
Quest Diagnostics test catalog
4 tests: codes, specimens, methods, preparation and reference intervals.
LOINC 27822-6
Regenstrief Institute codes that identify the same result across labs.
Search ClinicalTrials.gov for Protein S-Functional
Registered studies that measure Protein S-Functional, on the U.S. National Library of Medicine registry.
Verify these ranges and sources
We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.
Interpret your own results with a licensed clinician, or track your lab history and health goals in Aumnivida.
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