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Biomarkers · Chemical

Thyroid Peroxidase Antibody

A thyroid antibody test measures the level of thyroid antibodies in a sample of your blood to check for an autoimmune thyroid disease. Your thyroid is a small, butterfly-shaped gland in your neck.

Thyroid Antibody Tests, MedlinePlus, National Library of Medicine

The test measures thyroid antibodies in a blood sample to check for an autoimmune thyroid disease. Thyroid autoantibodies affect the thyroid's ability to make thyroid hormones, which shape how the body uses energy.

Also listed as
TPO, Thyroid Peroxidase Ab
Primary unit
IU/mL
LOINC codes
8099-4
Tests that measure Thyroid Peroxidase Antibody
Quest Diagnostics 9, Labcorp 6

See why clinicians order the test

  • Clinicians may order the test when other tests have already shown hypothyroidism or hyperthyroidism.

    Goal: Thyroid function

  • Clinicians read high TPO antibody levels as a sign that Hashimoto's disease is causing hypothyroidism.

    Condition: Hypothyroidism

  • Clinicians also use the test to screen for autoimmune thyroid disease when other thyroid results are too high or too low and risk is high.

    Goal: Thyroid function

Read with companion markers

  • T4, Free (Direct)

    T4 testing is one of the thyroid hormone checks that usually come first when clinicians look for thyroid dysfunction.

  • TSH

    TSH is one of the thyroid tests that usually come first when clinicians check for hypothyroidism or hyperthyroidism.

Prepare for the test

  • MedlinePlus says the thyroid antibody blood test needs no special preparation beforehand.

Each statement links to the source we wrote it from. Last updated October 19, 2026.

Ranges

Compare the reference ranges labs publish with guideline targets, diagnostic cut-offs, study-based ranges and practitioner targets. Move across the rows to check a value against each range, and open a source from the legend. How to read these ranges

Thyroid Peroxidase Antibody, IU/mL

Labs
  • Lab reference ranges2 labs
All 2 published ranges, with sources

Lab reference ranges

Tests

Check the catalog code, specimen, method and preparation for every test that measures Thyroid Peroxidase Antibody. Select up to five tests to compare them side by side.

Quest Diagnostics 9 tests

Single-analyte tests

  • Thyroid Peroxidase Antibodies (TPO) 5081

    Serum · Fasting not stated · Turnaround Set up: Mon-Fri (Day shift); Report available: 5 days

    Method and collection
    Method
    Immunoassay (IA)
    Collection
    Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.
    Reference notes
    <9 IU/mL
    Quest Diagnostics catalog page

  • TPO Antibody Endpoint 15116

    Serum · Fasting not stated · Turnaround Set up: Tues-Sat; Report available: 2 days

    Method and collection
    Method
    Immunoassay (IA)
    Reference notes
    <9 IU/mL
    Quest Diagnostics catalog page

Panels that include this biomarker

  • Thyroid Peroxidase and Thyroglobulin Antibodies 7260

    2 analytes · Serum · Fasting not stated

    Method and collection
    Method
    Immunoassay (IA)
    Collection
    Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.
    Reference notes
    Thyroid Peroxidase Ab | <9 IU/mL Thyroglobulin Ab | ≤2 IU/mL
    Quest Diagnostics catalog page

  • ANA Screen,IFA, with Reflex to Titer and Pattern/Sjogren's Panel 2 19880

    4 analytes · Serum · Fasting not stated

    Method and collection
    Method
    Immunoassay (IA) • Immunofluorescence Assay (IFA) • Immunoturbidimetric
    Reference notes
    See individual tests
    Quest Diagnostics catalog page

  • Chronic Urticaria Panel 1 16440

    4 analytes · Serum · Fasting not stated

    Method and collection
    Method
    See individual tests
    Preparation
    Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw. Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks after angiography. According to the assay manufacturer Siemens: samples containing fluorescein can produce falsely depressed values. Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
    Reference notes
    See individual tests
    Quest Diagnostics catalog page

  • Chronic Urticaria Panel 2 (Comprehensive) 90123

    5 analytes · Serum · Fasting not stated

    Method and collection
    Method
    See individual tests
    Preparation
    Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw. Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks after angiography. According to the assay manufacturer Siemens: samples containing fluorescein can produce falsely depressed values.
    Collection
    Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection).
    Reference notes
    See individual tests
    Quest Diagnostics catalog page

  • Primary Biliary Cholangitis (PBC) Diagnostic Panel 19876

    5 analytes · Serum · Fasting not stated

    Method and collection
    Method
    Immunoassay (IA)
    Reference notes
    See individual tests
    Quest Diagnostics catalog page

Labcorp 6 tests

Single-analyte tests

  • Anti-TPO Ab (RDL) 520018

    Serum · Fasting not stated · Turnaround 14 - 21 days

    Method and collection
    Method
    Chemiluminescent Immunoassay
    Collection
    Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
    Labcorp catalog page

  • Thyroid Peroxidase (TPO) Antibodies 006676

    Serum · Fasting not stated · Turnaround Within 1 day

    Method and collection
    Method
    Electrochemiluminescence immunoassay (ECLIA) This assay is performed on the Roche cobas instrument in multiple laboratories throughout Labcorp.
    Collection
    If a red-top tube or plasma is used, transfer separated serum or plasma to a plastic transport tube.
    Reference notes
    See table.1 Age | Range (IU/mL) 0 to 6 d | 0−117 7 d to 3 m | 0−47 4 to 11 m | 0−32 1 to 5 y | 0−13 6 to 10 y | 0−18 11 to 19 y | 0−26 >19 y | 0−34
    Labcorp catalog page

Panels that include this biomarker

  • Thyroid Antibodies 006684

    2 analytes · Serum · Fasting not stated · Turnaround 1 - 3 days

    Method and collection
    Method
    See individual test descriptions.
    Labcorp catalog page

  • ANA 12 Profile, Do All (RDL) 520299

    14 analytes · Serum · Fasting not stated · Turnaround 14 - 21 days

    Method and collection
    Method
    See individual test components.
    Collection
    Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
    Labcorp catalog page

  • ANA 12 Plus Profile, Do All (RDL) 520175

    17 analytes · Serum · Fasting not stated · Turnaround 14 - 21 days

    Method and collection
    Method
    ELISA, IFA, Farr RIA, Turbidimetry, CMIA
    Collection
    Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
    Labcorp catalog page

  • Chronic Urticaria (CU) Evaluation Profile 505805

    24 analytes · Serum · Fasting not stated · Turnaround 7 - 10 days

    Method and collection
    Method
    See individual tests.
    Collection
    CBC+ESR: Invert lavender-top tube eight to 10 times immediately after tube is filled at the time of collection. Other tests: If a red-top tube is used, transfer separated serum to a plastic transport tube.
    Labcorp catalog page

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Goals and conditions

We link Thyroid Peroxidase Antibody to these goals and conditions from named guidelines and studies.

Sources

Check the guidelines, studies and lab catalogs behind every range and link on this page. Open a source to see each claim it backs.

Clinical guidelines

Lab catalogs

Reference sources

Codes and registries

Verify these ranges and sources

We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

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