Sex Hormone Binding Globulin

Single-analyte tests

• Sex Hormone-binding Globulin 082016

  Serum · Fasting not stated · Turnaround Within 1 day

  Method and collection

  Method

  Electrochemiluminescence immunoassay (ECLIA) This assay is performed on the Roche cobas instrument in multiple laboratories throughout Labcorp.

  Collection

  If a red-top tube is used, transfer separated serum to a plastic transport tube.

  Reference notes

  • Male: − 20-49 years: 16.5−55.9 nmol/L − >49 years: 19.3−76.4 nmol/L • Female: − 20-49 years: 24.6−122.0 nmol/L − >49 years: 17.3−125.0 nmol/L

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Panels that include this biomarker

• Free Androgen Index (FAI) 146688

  3 analytes · Serum · Fasting not stated · Turnaround Within 1 day

  Method and collection

  Method

  Electrochemiluminescence immunoassay (ECLIA)

  Collection

  If a red-top tube is used, transfer separated serum to a plastic transport tube.

  Reference notes

  See table. Free Androgen Index Age | Male | Female 0 to 29 y | 30.0–128.0 | 0.4–8.4 30 to 39 y | 24.0–122.0 | 0.4–8.4 40 to 49 y | 14.0–126.0 | 0.4–8.4 >49 y | 18.0–82.0 | 0.4–6.6

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• Testosterone Free, Profile I 140226

  4 analytes · Serum · Fasting not stated · Turnaround Within 1 day

  Method and collection

  Method

  Albumin: Colorimetric Testosterone: Electrochemiluminescence immunoassay (ECLIA) SHBG: Electrochemiluminescence immunoassay (ECLIA)

  Collection

  If a red-top tube is used, transfer separated serum to a plastic transport tube.

  Reference notes

  See table.22 Testosterone, Free, Calc Age Male (pg/mL) Female (pg/mL) 0 to 1 y Not established Not established 2 to 5 y 0.1−0.5 0.2−0.7 6 to 7 y 0.1−0.9 0.4−7.6 8 y 0.2−0.8 0.4−7.6 9 y 0.2−1.4 0.4−7.6 10 y 0.3−3.6 0.4−7.6 11 y 0.3−7.9 0.4−7.6 12 y 0.6−32.0 0.4−7.6 13 y 1.4−98.1 1.6−15.4 14 y 8.5−105.6 1.6−15.4 15 y 14.0−128.1 1.6−15.4 16 y 30.5−147.6 1.6−15.4 17 y 38.7−157.6 1.6−15.4 18 to 30 y 47.7−173.9 1.1−12.9 31 to 40 y 42.3–190.0 0.7–7.9 41 to 50 y 30.3–183.2 0.5–6.0 51 to 60 y 35.8–168.2 0.4–6.7 61 to 70 y 34.7–150.3 0.4–7.0 71 to 80 y 31.7–120.8 0.3–5.7 81 to 100 y 20.7–97.4 0.2–5.6

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• Testosterone Free, Profile II 070130

  4 analytes · Serum · Fasting not stated · Turnaround 4 - 6 days

  Method and collection

  Method

  Albumin: Colorimetric Testosterone: Liquid chromatography/tandem mass spectrometry (LC/MS-MS) SHBG: Electrochemiluminescence immunoassay (ECLIA)

  Collection

  Serum should be transferred from cells within one hour of collection and transferred to a plastic transport tube.

  Reference notes

  See table.22 Age Male (pg/mL) Female (pg/mL) 0 to 1 y Not established Not established 2 to 5 y 0.1−0.5 0.2−0.7 6 to 7 y 0.1−0.9 0.4−7.6 8 y 0.2−0.8 0.4−7.6 9 y 0.2−1.4 0.4−7.6 10 y 0.3−3.6 0.4−7.6 11 y 0.3−7.9 0.4−7.6 12 y 0.6−32.0 0.4−7.6 13 y 1.4−98.1 1.6−15.4 14 y 8.5−105.6 1.6−15.4 15 y 14.0−128.1 1.6−15.4 16 y 30.5−147.6 1.6−15.4 17 y 38.7−157.6 1.6−15.4 18 to 30 y 47.7−173.9 1.1−12.9 31 to 40 y 42.3–190.0 0.7–7.9 41 to 50 y 30.3–183.2 0.5–6.0 51 to 60 y 35.8–168.2 0.4–6.7 61 to 70 y 34.7–150.3 0.4–7.0 71 to 80 y 31.7–120.8 0.3–5.7 81 to 100 y 20.7–97.4 0.2–5.6

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• Hirsutism Test Group I (Endocrine Sciences) 500066

  5 analytes · Serum · Fasting not stated · Turnaround 7 - 8 days

  Method and collection

  Method

  See individual assays.

  Collection

  Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested .

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• PCOS Diagnostic Profile 505550

  12 analytes · Serum · Fasting not stated · Turnaround 7 - 10 days

  Method and collection

  Method

  HPLC/tandem mass spectrometry (LC/MS-MS), Electrochemiluminescent (ECLIA), Immunochemiluminometric (ICMA), 2-site electrochemiluminescenceis

  Collection

  Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transport tube.

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Single-analyte tests

• Sex Hormone Binding Globulin (SHBG) 30740

  Serum · Fasting not stated · Turnaround Set up: Mon-Fri (Day shift); Report available: 5 days

  Method and collection

  Method

  Immunoassay (IA)

  Collection

  Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation. Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.

  Reference notes

  Male (nmol/L) | Female (nmol/L) <3 Years | Not Established | Not Established 3-9 Years | 32-158 | 32-158 10-13 Years | 20-166 | 24-120 14-17 Years | 20-87 | 12-150 18-55 Years | 10-50 | 17-124 >55 Years | 22-77 | 14-73

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Panels that include this biomarker

• Testosterone, Free (Dialysis), Total (MS) and Sex Hormone Binding Globulin 37073

  3 analytes · Serum · Fasting not stated

  Method and collection

  Method

  Chromatography/Mass Spectrometry • Equilibrium Dialysis • Calculation (CALC) • Immunoassay (IA)

  Collection

  Specify age and sex on test request form. Red-top tube (no gel): Allow blood to clot at room temperature. Centrifuge to separate the serum from the cells and immediately pour serum into a plastic transport tube. Serum separator tube: Allow blood to clot at room temperature, centrifuge, and remove serum from the gel immediately (not to exceed 48 hours) by pouring serum into a plastic transport tube. Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.

  Reference notes

  See Laboratory Report

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• Testosterone, Free, Bioavailable and Total, MS 14966

  4 analytes · Serum · Fasting not stated

  Method and collection

  Method

  Chromatography/Mass Spectrometry • Calculation (CALC) • Spectrophotometry (SP) • Immunochemiluminescent Assay

  Collection

  Specify age and sex on test request form. Red-top tube (no gel): Allow blood to clot at room temperature. Centrifuge to separate the serum from the cells and immediately pour serum into a plastic transport tube. Serum separator tube: Allow blood to clot at room temperature, centrifuge, and remove serum from the gel immediately (not to exceed 48 hours) by pouring serum into a plastic transport tube. Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.

  Reference notes

  See Laboratory Report

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• Testosterone, Free, Bioavailable and Total, Males (Adult), Immunoassay 30741

  5 analytes · Serum · Fasting not stated

  Method and collection

  Preparation

  Testosterone, Total, Males (Adult), Immunoassay: Due to changes in testosterone levels throughout the day, two morning (8:00-10:00 a.m.) specimens obtained on different days are recommended by The Endocrine Society for screening.

  Collection

  Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

  Reference notes

  Testosterone, Total, Males (Adult), Immunoassay Male 250-827 ng/dL Female Not applicable All test requests for Testosterone on female and pediatric (<18 years) patients must use test code 15983 - Testosterone, Total, MS. Albumin 3.6-5.1 g/dL Sex Hormone Binding Globulin Age Male (nmol/L) Female (nmol/L) <3 Years Not established Not established 3-9 Years 32-158 32-158 10-13 Years 20-166 24-120 14-17 Years 20-87 12-150 18-55 Years 10-50 17-124 >55 Years 22-77 14-73 Free Testosterone Age Male (pg/mL) Female 18-69 Years 46.0-224.0 Not applicable >69 Years 6.0-73.0 Not applicable Bioavailable Testosterone Age Male (ng/dL) Female 18-69 Years 110.0-575.0 Not applicable >69 Years 15.0-150.0 Not applicable

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