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Biomarkers · Chemical

Uroporphyrins, Urine

Also listed as
UP
Primary unit
ug/L
LOINC codes
11228-4
Tests that measure Uroporphyrins, Urine
Labcorp 2

Tests

Check the catalog code, specimen, method and preparation for every test that measures Uroporphyrins, Urine. Select up to five tests to compare them side by side.

Labcorp 2 tests

Panels that include this biomarker

  • Porphyrins, Quantitative, Random Urine 120980

    6 analytes · Urine · Fasting not stated · Turnaround 3 - 5 days

    Method and collection
    Method
    High-pressure liquid chromatography (HPLC) with fluorometric detection
    Collection
    Transfer required aliquot into a LabCorp amber plastic transport tube with amber cap (LabCorp No. 23598). (If amber transport tubes are unavailable, cover transport tube completely, top and bottom, with aluminum foil. Identify specimen with patient's name directly on the amber transport tube and on the outside of the aluminum foil. Secure with tape.) Specimen must be kept refrigerated during transport.
    Reference notes
    • Coproporphyrin (CP) I: 0−15 μg/L • Coproporphyrin (CP) III: 0−49 μg/L • Heptacarboxylporphyrins (7-CP): 0−2 μg/L • Hexacarboxylporphyrins (6-CP): 0−1 μg/L • Pentacarboxylporphyrins (5-CP): 0−2 μg/L • Uroporphyrins (UP): 0−20 μg/L
    Labcorp catalog page

  • Porphyrins, Quantitative, 24-Hour Urine 003194

    12 analytes · Urine · Fasting not stated · Turnaround 3 - 7 days

    Method and collection
    Method
    High-pressure liquid chromatography (HPLC) with fluorometric detection
    Collection
    Instruct patient to void at 8 AM (or 8 PM) and discard the specimen. Then collect all the urine, including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM [or 8 PM] the following day). Mix well. Measure and record total urine volume on the test request form, along with the patient's name, date, and time collection started and finished. Transfer required aliquot into a LabCorp amber plastic transport tube with amber cap (LabCorp N° 23598). (If amber transport tubes are unavailable, cover transport tube completely, top and bottom, with aluminum foil. Identify specimen with patient's name directly on the amber transport tube and on the outside of the aluminum foil. Secure with tape.) Specimen must be kept refrigerated during transport.
    Reference notes
    • Coproporphyrin (CP) I: 0−24 μg/24 hours • Coproporphyrin (CP) III: 0−74 μg/24 hours • Heptacarboxylporphyrins (7-CP): 0−4 μg/24 hours • Hexacarboxylporphyrins (6-CP): 0−1 μg/24 hours • Pentacarboxylporphyrins (5-CP): 0−4 μg/24 hours • Uroporphyrins (UP): 0−24 μg/24 hours See table. Pattern of the Different Porphyrias Disease Uro Hepta Hexa Penta Copro I Copro III + = increased; ++ = strongly increased; n = normal; v = varies. Values from: Doss M. Porphyrinstoffwechsel. In: Greiling H, Gressner AM (Hrsg). Lehrbuch der Klinischen Chemie und Pathobiochemie. Dritte Auflage. Stuttgart, Germany: Schattauer Verlag. Values marked with * and ** respectively, are derived from: *Hindmarsh JT, Oliveras L, Greenway DC. Biochemical differentiation of the porphyrias. Clin Biochem. 1999 Nov; 32(8):609-619. **Elder GH, Smith SG, Smyth SJ. Laboratory investigation of the porphyrias. Ann Clin Biochem. 1990 Sep; 27(Pt 5):395-412. Porphyria cutanea tarda (PCT) ++ ++ + + +* +* Acute intermittent porphyria (AIP) ++ + + ++ +* ++* Porphyria variegata (VP) ++ + + ++ +* ++* Hereditary coproporphyria (CP) + + + ++ n* ++* Protoporphyria v n n v +* v Morbus Gunther ++ + + + ++** Porphobilinogen synthase deficiency + + + ++ ++
    Labcorp catalog page

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We compile this page from named laboratory catalogs, guidelines and studies. Labs calculate reference intervals from the people they test, for one assay method and one population group, so an interval describes that population rather than an optimal target.

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